Associate Director, GxP Systems

🕒 Maio 27

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Vera Therapeutics, Inc.

SiteLinkedInTodas as Vagas

201 - 500 funcionários

🧬 Biotecnologia

💊 Farmacêutico

Biotechnology • Pharmaceuticals

Vera Therapeutics, Inc. é uma empresa de biotecnologia em estágio clínico focada no desenvolvimento de tratamentos para doenças renais imunológicas que melhorem a vida dos pacientes. A empresa está avançando com o Atacicept através do desenvolvimento clínico para nefropatia por IgA (IgAN), conduzindo testes de Fase 2b e Fase 3, e perseguindo programas em nefrite lúpica e outras condições imunológicas. Com sede em Brisbane, CA, a Vera enfatiza o desenvolvimento de medicamentos orientado pela ciência, o engajamento com os pacientes e a sustentabilidade.

Descrição

• Serve as the System Owner and hands-on administrator for GxP systems (e.g., TraceLink, Lorenz DocuBridge, Egnyte Life Sciences, ZenQMS, Global Vision, Veeva), overseeing system lifecycle, performance, and compliance • Participate in system implementation activities, including vendor selection, requirements gathering, testing, and deployment to ensure alignment with business and regulatory needs • Provide oversight and direction for Computer System Validation (CSV) activities and validation documentation, partnering with the Validation Engineer to ensure regulatory compliance and audit readiness • Own and lead Change Control processes for all GxP systems, including impact assessments, risk evaluations, documentation, coordination of testing, and release management • Perform system administration activities, including user access provisioning, role management, periodic access reviews, and audit trail monitoring • Oversee system maintenance, enhancements, and issue resolution (e.g., upgrades, patches, changes), ensuring appropriate validation impact assessments, documentation updates, and minimal business disruption • Collaborate with IT and vendors to support integration, system performance optimization, and resolution of technical issues • Develop and maintain system-related documentation, including SOPs, Systems Inventory, administrative procedures, and work instructions in collaboration with Quality Assurance and business stakeholders • Provide SME support during FDA audits and inspections, including preparation, documentation review, and representation of system controls and validation status • Drive continuous improvement by identifying gaps, inefficiencies, and opportunities for system scalability and automation • Translate business requirements into effective system solutions, acting as a key liaison between business stakeholders and technical teams • Manage project timelines, risks, and deliverables to ensure successful and compliant execution of system initiatives

🎯 Requisitos

• Bachelor’s degree in Life Sciences, Information Systems, Computer Science, Engineering, or a related field; advanced degree preferred • 10-12 years of hands-on experience with GxP systems in Life Sciences, including system administration, validation oversight, and operational support • Proven experience implementing and validating systems such as eQMS, TraceLink, LMS, Validated Documents and Data storage solutions (such as Box for GxP or Egnyte Life Sciences), or ERP systems (e.g., NetSuite, Oracle, SAP) in a GxP-regulated environment • Strong understanding of CSV, data integrity, Part 11 compliance, and regulatory expectations (FDA, EMA, ICH) • Experience partnering with validation/CSV resources while maintaining accountability for system compliance and validation outcomes • Proven experience owning and managing Change Control processes for GxP systems • Experience supporting pre-commercial biotech organizations transitioning to commercialization • Ability to balance strategic oversight with hands-on system administration and operational responsibilities • Strong cross-functional collaboration skills across IT, QA, Regulatory, and Technical Operations • Experience managing vendors and implementation partners • Excellent troubleshooting, analytical, and problem-solving skills • Strong communication skills with the ability to translate technical concepts into business terms and influence stakeholders.