Bicycle Therapeutics
201 - 500 employees
Founded 2015
🧬 Biotechnology
💊 Pharmaceuticals
🔬 Science
💰 $175M Post-IPO Equity on 2021-10
Biotechnology • Pharmaceuticals • Science
Bicycle Therapeutics is a biotechnology company focused on developing precision-guided therapeutics to target intractable cancers and other serious diseases. Their mission is to create innovative medicines that have a transformative impact on patient lives by penetrating deep into tissues to address hard-to-target areas. While the company's primary focus is on solid tumor cancers, their technology also holds promise for a variety of therapeutic applications beyond oncology, such as anti-infective and cardiovascular treatments. Bicycle Therapeutics collaborates with pharmaceutical partners and academic leaders to explore new applications of their unique technology.
Senior Scientist, In Vivo Pharmacology – Radiopharmaceuticals
🔥 0 minutes ago
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Bicycle Therapeutics
201 - 500 employees
Founded 2015
🧬 Biotechnology
💊 Pharmaceuticals
🔬 Science
💰 $175M Post-IPO Equity on 2021-10
Biotechnology • Pharmaceuticals • Science
Bicycle Therapeutics is a biotechnology company focused on developing precision-guided therapeutics to target intractable cancers and other serious diseases. Their mission is to create innovative medicines that have a transformative impact on patient lives by penetrating deep into tissues to address hard-to-target areas. While the company's primary focus is on solid tumor cancers, their technology also holds promise for a variety of therapeutic applications beyond oncology, such as anti-infective and cardiovascular treatments. Bicycle Therapeutics collaborates with pharmaceutical partners and academic leaders to explore new applications of their unique technology.
📋 Description
• Your mission is to apply your deep expertise in in vivo pharmacology to drive the preclinical evaluation of our innovative Bicycle® Radio Conjugates (BRCs). • Independently execute and interpret key preclinical studies to generate critical data needed to understand their activity, guide their optimization, and support the advancement of our next-generation cancer therapies. • Design, execution, and interpretation of in vivo pharmacology studies to evaluate the biodistribution, mechanism of action, and PK/PD/efficacy relationships of our BRCs. • Manage the execution of in vivo studies through a network of CROs and academic collaborators, ensuring timely delivery of high-quality data. • Act as a key technical expert on cross-functional project teams, collaborating with chemistry, biology, DMPK, and toxicology experts to contribute to project goals. • Contribute to the identification and validation of pharmacodynamic biomarkers to support preclinical and clinical development. • Perform hands-on in vivo experimental work as required to support project progression and ensure timely data delivery. • Effectively document and communicate complex study results and their interpretation to project teams and in broader scientific forums. • Contribute to publications for peer-reviewed journals and present data at scientific conferences. • Act as a source of technical expertise for the team, sharing best practices in in vivo techniques and radiopharmaceutical handling.
🎯 Requirements
• Strong experience in in vivo pharmacology and tumour biology, gained in a biopharmaceutical or academic setting. • Essential hands-on experience in preclinical radiopharmaceutical assessment, including PET/SPECT imaging and ex vivo biodistribution analysis. • Experience working with external CROs or academic collaborators to execute studies. • Experience with radionuclide- or toxin-conjugates (e.g., radiopharmaceuticals, ADCs) and a background in cancer biology is required. • Excellent attention to detail and strong organizational and communication skills. • Knowledge of radiochemistry, radiolabelling, or dosimetry would be an advantage. • A current Home Office Personal License (PIL) is highly desirable
🏖️ Benefits
• State-of-the-art campus environment with on campus restaurant and Montessori nursery • Flexible working environment • Competitive reward including annual company bonus • Employee recognition schemes • 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually • Employer contribution to pension (employee does not have to contribute) • Life assurance cover 4x basic salary • Private Medical Insurance, including optical and dental cover • Enhanced parental leave policies • Group income protection • Employee assistance program • Health Cash Plan • Access to company subsidized gym membership • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. • Cycle to work scheme
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