Senior Director, Oncology Pharmacology

🕒 June 29

🌐 United States, United Kingdom – Remote

🇺🇸 United States – Remote 🇬🇧 United Kingdom – Remote

🏄 California, Pennsylvania – Remote

🏄 California – Remote 🔔 Pennsylvania – Remote

💵 $232k - $348k / year

⏰ Full Time

🟠 Senior

👔 Director

🦅 H1B Visa Sponsor

This company has sponsored H1B visas in the past.

👻 Ghost score 36%

What it means: how likely this posting is sitting open without active hiring.How to read it: 60% or higher means we think this is a ghost. Lower scores are less of a worry.How we score it: age, reposts, open roles vs team size, how fast jobs close, and whether pay is listed.Fine print: an estimate from public data, not a judgment of the company. Real jobs can score high, so treat it as a hint, not a fact.

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Jazz Pharmaceuticals

WebsiteLinkedInAll Job Openings

1001 - 5000 employees

Founded 2003

🏥 Healthcare

🏭 Manufacturing

🧬 Biotechnology

Healthcare • Manufacturing • Biotechnology

Jazz Pharmaceuticals is a biopharmaceutical company dedicated to developing innovative medicines that address serious unmet medical needs. With a strong commitment to research and development, Jazz focuses on creating life-changing therapies, emphasizing the importance of collaboration, diversity, and employee engagement in its operations. The company prides itself on transforming patients' lives through its meaningful product offerings and a culture that fosters enthusiasm and flexibility.

📋 Description

• Lead scientific team members assigned to oncology assets from discovery through regulatory approval • Manage the oncology pharmacology team while serving as a lead on one or more programs • Establish efficacy in relevant disease models and demonstrate differentiation relative to relevant comparators • Determine PK/PD/efficacy relationships and characterize mechanisms of action • Identify predictive disease models, indications, and biomarkers • Drive preclinical discovery and support research and development of Jazz products and drug candidates • Design and execute studies addressing clinically relevant priorities • Design and execute outsourced, in-house, and academic-collaborator experiments • Review and contribute to clinical protocols • Review and author technical reports • Coauthor regulatory documents from IND to NDA/BLA submissions • Communicate research at internal and external forums • Collaborate with Clinical Development, Bioanalytical, Toxicology, Clinical Pharmacology, Biomarkers, Regulatory Affairs, and Project Management teams • Design, develop, implement, and oversee strategies and experiments supporting nonclinical studies in hematologic malignancies and solid tumors • Lead experiments involving efficacy, tolerability, mechanism of action, and biomarkers across multiple therapeutic modalities • Collaborate with CROs to outsource studies, develop protocols, manage timelines and budgets, and partner with academic labs • Serve as project team leader or lead pharmacology representative across oncology programs • Mentor junior scientists and provide scientific leadership and professional growth opportunities

🎯 Requirements

• Industry experience evaluating therapeutic potential of drug candidates from hit to lead optimization through discovery to late phase studies, with deep expertise in oncology drug development • Broad background in preclinical oncology with strong familiarity with emerging therapeutic modalities, competitive landscapes, and strategic assessment of diverse drug mechanisms • Extensive experience in Immuno Oncology (I/O), including I/O relevant in vivo and in vitro models, immune cell biology, and integration of immunological endpoints into pharmacology programs • Demonstrated experience working across multiple drug modalities, including small molecules, biologics, ADCs, bi-specifics, T cell engagers, cell and gene therapies, and RNA based therapeutics • Strong foundational understanding of the interdependencies between Nonclinical Pharmacology, Toxicology, DMPK, and Clinical Pharmacology • Deep understanding of cancer signaling pathways and their therapeutic exploitation • Proven experience leading multiple complex pharmacology programs at diverse CROs, including GLP and non-GLP environments • Expertise designing and executing studies evaluating efficacy, tolerability, mechanism of action, and biomarker strategies for small molecule and biologic agents • Ability to integrate preclinical and clinical datasets, innovate, and apply novel methodologies to advance therapeutic programs • Proficiency with analytical tools (e.g., GraphPad Prism) and biomarker data analysis • Direct people management experience, including mentorship, performance development, and leadership of scientific teams • Strong leadership qualities, self motivation, and demonstrated success networking across internal teams, academia, industry, and regulatory agencies • Excellent ability to assess program needs, oversee CRO activities, develop/review protocols, monitor execution, interpret results, and prepare high quality reports for regulatory submissions • Experience authoring nonclinical components of IND, NDA/BLA/MAA submissions, briefing packages, DSURs, IBs, and fast track designation documents • Strong project management skills with the ability to manage multiple complex programs simultaneously • Demonstrated success leading in fast paced, highly matrixed environments, aligning diverse stakeholders and driving decision making • Strong analytical and creative problem-solving skills • Ph.D. in biology, biochemistry, immunology, pharmacology, or a related discipline, with experience leading early oncology programs and developing nonclinical models for characterizing therapeutic efficacy and pharmacodynamics, including substantial oncology and immuno-oncology experience

🏖️ Benefits

• Discretionary annual cash bonus or incentive compensation • Discretionary equity grants • Medical insurance • Dental insurance • Vision insurance • 401k retirement savings plan • Flexible paid vacation