Executive Director – Protein Engineering, Chemistry

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Shasqi

SiteLinkedInTodas as Vagas

11 - 50 funcionários

Fundada em 2015

🧬 Biotecnologia

💊 Farmacêutico

💰 $1.900.000 Grant em 2022-01

Biotechnology • Pharmaceuticals

A Shasqi é uma empresa de biotecnologia em estágio clínico que desenvolve uma plataforma de terapia tumoral pré-alvo chamada CAPAC (Click Activated Protodrugs Against Cancer), que utiliza química clic in-vivo para capturar e ativar cargas terapêuticas em tumores. Sua abordagem modular separa uma molécula clicável de ligação ao tumor de uma carga útil clicável inativa (radioisótopo ou protodroga de quimioterapia) que se torna ativada ou bloqueada no tumor após uma reação clic bio-ortogonal, visando aumentar a concentração do medicamento no tumor e reduzir a toxicidade sistêmica. A Shasqi relata validação clínica da plataforma e está avançando com ativos do pipeline e colaborações para levar terapias contra o câncer pré-alvo aos pacientes.

Descrição

• Lead the protein engineering and chemistry teams toward design, discovery, engineering, and optimization of therapeutic candidates, including biologic binders, chemical payloads, and technologies to enable pre-targeting with click chemistry. • Personally contribute to molecular design strategy, candidate selection, and developability assessment for both biologic binders and chemical payloads. • Guide strategy for protein characterization, including biophysical, biochemical, and functional evaluation. • Establish and implement strategies for lead optimization, focusing on affinity, specificity, stability, manufacturability, and developability. • Ensure candidates are designed with manufacturability, scalability, and regulatory requirements in mind. • Lead internal team working with CDMOs and CROs to advance: • Cell line development • Process development • Analytical development • GMP Manufacturing • Regulatory requirements • Contribute to IND-enabling activities and regulatory documentation. • Build, lead, manage, and mentor a high-performing protein engineering and chemistry team. • Lead team toward defining departmental goals and strategy aligned with research and company goals. • Lead team to manage internal and external collaborations, including CROs and academic partners. • Serve as a scientific leader and key contributor to portfolio strategy and candidate selection decisions. • Maintain awareness of emerging technologies in protein engineering, novel payloads, and pre-targeting. • Identify and implement new tools and platforms to enhance engineering capabilities. • Represent the company at scientific conferences and external meetings as appropriate.

🎯 Requisitos

• Ph.D. in Biochemistry, Protein Engineering, Chemistry, Chemical Biology, or related discipline. • Minimum 12+ years of relevant industry experience working in therapeutic discovery and development of either: • Biologics and small molecules, or • Small molecule-biologic conjugates. • Minimum 5+ years of leadership experience managing scientific teams. • Demonstrated track record of advancing biologic-based therapies into clinical development. • Direct experience supporting biologic CMC development, IND submissions, and clinical-stage programs is required. • Small format biologic discovery and protein engineering. • Experience with chemical biology or medicinal chemistry. • Targeted therapies. • Structure-based design and protein optimization. • Biophysical and biochemical characterization methods. • Developability assessment and manufacturability considerations. • Protein chemistry, conjugation, and modification strategies.

🏖️ Benefícios

• Competitive base salary as part of a broader total rewards package. • Equity: Included as part of total compensations. • Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability. • Flexible PTO and a WFH stipend to support remote work. • Ongoing growth opportunities, professional development, and mentorship.