Senior Director, Oncology Pharmacology

🕒 vor 4 Monaten

🌐 Vereinigte Staaten, Vereinigtes Königreich – Remote

🇺🇸 Vereinigte Staaten – Remote 🇬🇧 Vereinigtes Königreich – Remote

🏄 California, Pennsylvania – Remote

🏄 California – Remote 🔔 Pennsylvania – Remote

💵 $232.000 - $348.000 / Jahr

⏰ Vollzeit

🟠 Senior

👔 Direktor

🦅 H1B-Visum-Sponsor

Dieses Unternehmen hat in der Vergangenheit H1B-Visa gesponsert.

👻 Geisterscore 43%

Was es bedeutet: die Wahrscheinlichkeit, dass für diese Stelle niemand wirklich einstellt.So liest du es: 60 % oder höher heißt, wir halten das für einen Geisterjob. Niedrigere Werte sind weniger bedenklich.Wie wir werten: Dauer offen, Neuveröffentlichungen, offene Stellen vs Teamgröße, wie schnell Stellen geschlossen werden, und ob ein Gehalt angegeben ist.Hinweis: eine Schätzung aus öffentlichen Daten, kein Urteil über das Unternehmen. Echte Stellen können hoch punkten, nutze es also als Hinweis, nicht als Fakt.

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Jazz Pharmaceuticals

WebsiteLinkedInAlle Stellen

1001 - 5000 Mitarbeiter

Gegründet 2003

🏥 Gesundheitswesen

🏭 Fertigung

🧬 Biotechnologie

Healthcare • Manufacturing • Biotechnology

Jazz Pharmaceuticals ist ein biopharmazeutisches Unternehmen, das sich der Entwicklung innovativer Medikamente widmet, um ernsthafte ungedeckte medizinische Bedürfnisse zu adressieren. Mit einem starken Engagement für Forschung und Entwicklung konzentriert sich Jazz auf die Schaffung lebensverändernder Therapien und betont dabei die Bedeutung von Zusammenarbeit, Vielfalt und Mitarbeiterengagement in seinen Prozessen. Das Unternehmen ist stolz darauf, die Leben der Patienten durch seine bedeutungsvollen Produktangebote zu transformieren und eine Kultur zu fördern, die Begeisterung und Flexibilität unterstützt.

Beschreibung

• Lead scientific team members assigned to oncology assets from discovery through regulatory approval • Manage the oncology pharmacology team while serving as a lead on one or more programs • Establish efficacy in relevant disease models and demonstrate differentiation relative to relevant comparators • Determine PK/PD/efficacy relationships and characterize mechanisms of action • Identify predictive disease models, indications, and biomarkers • Drive preclinical discovery and support research and development of Jazz products and drug candidates • Design and execute studies addressing clinically relevant priorities • Design and execute outsourced, in-house, and academic-collaborator experiments • Review and contribute to clinical protocols • Review and author technical reports • Coauthor regulatory documents from IND to NDA/BLA submissions • Communicate research at internal and external forums • Collaborate with Clinical Development, Bioanalytical, Toxicology, Clinical Pharmacology, Biomarkers, Regulatory Affairs, and Project Management teams • Design, develop, implement, and oversee strategies and experiments supporting nonclinical studies in hematologic malignancies and solid tumors • Lead experiments involving efficacy, tolerability, mechanism of action, and biomarkers across multiple therapeutic modalities • Collaborate with CROs to outsource studies, develop protocols, manage timelines and budgets, and partner with academic labs • Serve as project team leader or lead pharmacology representative across oncology programs • Mentor junior scientists and provide scientific leadership and professional growth opportunities

🎯 Anforderungen

• Industry experience evaluating therapeutic potential of drug candidates from hit to lead optimization through discovery to late phase studies, with deep expertise in oncology drug development • Broad background in preclinical oncology with strong familiarity with emerging therapeutic modalities, competitive landscapes, and strategic assessment of diverse drug mechanisms • Extensive experience in Immuno Oncology (I/O), including I/O relevant in vivo and in vitro models, immune cell biology, and integration of immunological endpoints into pharmacology programs • Demonstrated experience working across multiple drug modalities, including small molecules, biologics, ADCs, bi-specifics, T cell engagers, cell and gene therapies, and RNA based therapeutics • Strong foundational understanding of the interdependencies between Nonclinical Pharmacology, Toxicology, DMPK, and Clinical Pharmacology • Deep understanding of cancer signaling pathways and their therapeutic exploitation • Proven experience leading multiple complex pharmacology programs at diverse CROs, including GLP and non-GLP environments • Expertise designing and executing studies evaluating efficacy, tolerability, mechanism of action, and biomarker strategies for small molecule and biologic agents • Ability to integrate preclinical and clinical datasets, innovate, and apply novel methodologies to advance therapeutic programs • Proficiency with analytical tools (e.g., GraphPad Prism) and biomarker data analysis • Direct people management experience, including mentorship, performance development, and leadership of scientific teams • Strong leadership qualities, self motivation, and demonstrated success networking across internal teams, academia, industry, and regulatory agencies • Excellent ability to assess program needs, oversee CRO activities, develop/review protocols, monitor execution, interpret results, and prepare high quality reports for regulatory submissions • Experience authoring nonclinical components of IND, NDA/BLA/MAA submissions, briefing packages, DSURs, IBs, and fast track designation documents • Strong project management skills with the ability to manage multiple complex programs simultaneously • Demonstrated success leading in fast paced, highly matrixed environments, aligning diverse stakeholders and driving decision making • Strong analytical and creative problem-solving skills • Ph.D. in biology, biochemistry, immunology, pharmacology, or a related discipline, with experience leading early oncology programs and developing nonclinical models for characterizing therapeutic efficacy and pharmacodynamics, including substantial oncology and immuno-oncology experience

🏖️ Vorteile

• Discretionary annual cash bonus or incentive compensation • Discretionary equity grants • Medical insurance • Dental insurance • Vision insurance • 401k retirement savings plan • Flexible paid vacation

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