Executive Director – Protein Engineering, Chemistry

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Shasqi

Site WebLinkedInTous les Emplois

11 - 50 employés

Fondée en 2015

🧬 Biotechnologie

💊 Pharmaceutique

💰 €1 900 000 Grant en 2022-01

Biotechnology • Pharmaceuticals

Shasqi est une entreprise de biotechnologie en phase clinique développant une plateforme de thérapie des tumeurs pré-ciblée appelée CAPAC (Click Activated Protodrugs Against Cancer) qui utilise la chimie click in-vivo pour capturer et activer des charges thérapeutiques sur les tumeurs. Leur approche modulaire sépare une molécule cliquable ciblant la tumeur d'une charge cliquable inerte (radio-isotope ou prodrogue de chimiothérapie) qui devient activée ou verrouillée sur la tumeur après une réaction click bioorthogonale, visant à augmenter la concentration de médicaments dans la tumeur et à réduire la toxicité systémique. Shasqi rapporte une validation clinique de la plateforme et fait progresser les actifs de son pipeline et ses collaborations pour apporter des thérapies anticancéreuses pré-ciblées aux patients.

Description

• Lead the protein engineering and chemistry teams toward design, discovery, engineering, and optimization of therapeutic candidates, including biologic binders, chemical payloads, and technologies to enable pre-targeting with click chemistry. • Personally contribute to molecular design strategy, candidate selection, and developability assessment for both biologic binders and chemical payloads. • Guide strategy for protein characterization, including biophysical, biochemical, and functional evaluation. • Establish and implement strategies for lead optimization, focusing on affinity, specificity, stability, manufacturability, and developability. • Ensure candidates are designed with manufacturability, scalability, and regulatory requirements in mind. • Lead internal team working with CDMOs and CROs to advance: • Cell line development • Process development • Analytical development • GMP Manufacturing • Regulatory requirements • Contribute to IND-enabling activities and regulatory documentation. • Build, lead, manage, and mentor a high-performing protein engineering and chemistry team. • Lead team toward defining departmental goals and strategy aligned with research and company goals. • Lead team to manage internal and external collaborations, including CROs and academic partners. • Serve as a scientific leader and key contributor to portfolio strategy and candidate selection decisions. • Maintain awareness of emerging technologies in protein engineering, novel payloads, and pre-targeting. • Identify and implement new tools and platforms to enhance engineering capabilities. • Represent the company at scientific conferences and external meetings as appropriate.

🎯 Exigences

• Ph.D. in Biochemistry, Protein Engineering, Chemistry, Chemical Biology, or related discipline. • Minimum 12+ years of relevant industry experience working in therapeutic discovery and development of either: • Biologics and small molecules, or • Small molecule-biologic conjugates. • Minimum 5+ years of leadership experience managing scientific teams. • Demonstrated track record of advancing biologic-based therapies into clinical development. • Direct experience supporting biologic CMC development, IND submissions, and clinical-stage programs is required. • Small format biologic discovery and protein engineering. • Experience with chemical biology or medicinal chemistry. • Targeted therapies. • Structure-based design and protein optimization. • Biophysical and biochemical characterization methods. • Developability assessment and manufacturability considerations. • Protein chemistry, conjugation, and modification strategies.

🏖️ Avantages

• Competitive base salary as part of a broader total rewards package. • Equity: Included as part of total compensations. • Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability. • Flexible PTO and a WFH stipend to support remote work. • Ongoing growth opportunities, professional development, and mentorship.