Associate Director of Bioinformatics – Women's Health, Organ Health

🔥 14 horas atrás

🇺🇸 Estados Unidos – Remoto (EUA)

💵 $166.600 - $202.000 / ano

⏰ Tempo Integral

🟠 Sênior

👔 Diretor

🦅 Patrocina Visto H1B

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🗣️🇺🇸🇬🇧 Inglês obrigatório

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Natera

1001 - 5000 funcionários

Fundada em 2004

🏥 Saúde

🧬 Biotecnologia

⚕️ Seguro de Saúde

Healthcare • Biotechnology • Healthcare Insurance

A Natera é líder global em tecnologia de testes de DNA livre de células (cfDNA), especializada em testes e diagnósticos genéticos não invasivos. As soluções inovadoras da empresa concentram-se em áreas como triagem pré-natal, detecção de câncer e monitoramento de transplantes de órgãos. Ao utilizar bioinformática avançada e análise de DNA, a Natera oferece a profissionais de saúde e pacientes informações essenciais para decisões médicas mais embasadas.

Descrição

• Lead and mentor a team of Bioinformatics Scientists, owning their professional growth, responsibilities, and standards • Own the research strategy for new product development from scoping through execution • Lead bioinformatics analysis for assay development and optimization, troubleshooting experiments with laboratory scientists • Work across methylation, fragmentomics, other cfDNA-derived features, short-read and long-read sequencing, hybrid-capture, and amplicon target enrichment • Partner with laboratory teams on research and feasibility study design, technology assessment, optimization, and performance determination • Improve analysis pipelines for variant detection, quality control, methylation calling, fragment-size and end-motif analysis, error suppression, and structural-variant calling • Move research prototypes into stable production workflows using version control, testing, continuous integration and delivery, and containerization • Automate research data management, pipeline execution, and reporting • Establish standards for appropriate AI-agent-assisted work and scientist sign-off • Collaborate with data science, molecular biology, pipeline engineering, biostatistics, quality assurance, and laboratory operations • Serve as a bioinformatics subject-matter expert and communicate findings and roadmaps across the company • Own the team research roadmap and ensure research methods reach production code and demonstrate expected benchmark performance

🎯 Requisitos

• Ph.D. in Bioinformatics, Computational Biology, Computer Science, Mathematics, Engineering, Biostatistics, or a related field; an M.S. with equivalent experience is considered • 7+ years in bioinformatics, including 3+ years leading scientists and working across functions • Demonstrated ownership of a team that took scientific research into real clinical use • Demonstrated experience developing or scientifically guiding diagnostic sequencing assays • Deep expertise in next-generation sequencing analysis, including hybrid-capture or amplicon-based target enrichment, sequencing quality control, secondary analysis, and variant calling • Experience with cell-free DNA sequencing and other omics data, especially in diagnostics • Working knowledge of diagnostic product development in a regulated, accredited setting • Strong Python, programming, and data analysis skills • Fluency in exploratory data analysis and visualization on complex datasets • Ability to translate findings into actionable recommendations • Understanding of sequencing workflows from sample extraction through the instrument • Demonstrated record of assessing a new platform, assay chemistry, or method against established benchmarks • Long-read sequencing, including PacBio HiFi or Oxford Nanopore, in addition to short-read Illumina sequencing • R, shell scripting, or Java • Cloud computing with AWS or GCP and workflow orchestration with Snakemake, WDL, Nextflow, or Cromwell • Containerization with Docker or Kubernetes for reproducible, production-grade analyses • Conference presentations or peer-reviewed publications may be advantageous

🏖️ Benefícios

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents • Free testing for Natera employees and their immediate families • Fertility care benefits • Pregnancy and baby bonding leave • 401(k) benefits • Commuter benefits • Employee referral program

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