Dianthus Therapeutics, Inc.
Biotechnology • Pharmaceuticals
Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing novel monoclonal antibodies to treat severe autoimmune and inflammatory diseases. The company leverages advanced antibody engineering technologies to create next-generation complement therapeutics with improved selectivity and potency. Its lead program, DNTH103, is a monoclonal antibody targeting the classical complement pathway for conditions such as generalized Myasthenia Gravis, Multifocal Motor Neuropathy, and Chronic Inflammatory Demyelinating Polyneuropathy. Based in New York City and Waltham, Massachusetts, Dianthus aims to deliver transformative medicinal therapies by addressing unmet needs in autoimmune treatment.
2 - 10 employees
Founded 2017
🧬 Biotechnology
💊 Pharmaceuticals
💰 $100M Private Equity Round on 2022-04
Director, Drug Substance – Early Development
November 7
Dianthus Therapeutics, Inc.
Biotechnology • Pharmaceuticals
Dianthus Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing novel monoclonal antibodies to treat severe autoimmune and inflammatory diseases. The company leverages advanced antibody engineering technologies to create next-generation complement therapeutics with improved selectivity and potency. Its lead program, DNTH103, is a monoclonal antibody targeting the classical complement pathway for conditions such as generalized Myasthenia Gravis, Multifocal Motor Neuropathy, and Chronic Inflammatory Demyelinating Polyneuropathy. Based in New York City and Waltham, Massachusetts, Dianthus aims to deliver transformative medicinal therapies by addressing unmet needs in autoimmune treatment.
2 - 10 employees
Founded 2017
🧬 Biotechnology
💊 Pharmaceuticals
💰 $100M Private Equity Round on 2022-04
📋 Description
• Lead MSAT activities for monoclonal antibodies and fusion proteins, from early development through clinical manufacturing. • Oversee cell line development, clone selection, and characterization in collaboration with internal teams and external partners. • Design and optimize bioreactor processes (shake flask to pilot scale) to ensure scalability, robustness, and regulatory compliance. • Drive formulation development strategies for early-phase programs, ensuring compatibility with downstream processing and stability requirements. • Collaborate cross-functionally with Analytical Development, Downstream Process Development, Quality, Regulatory, and Clinical Supply teams. • Serve as a technical SME during tech transfer to CDMOs and during regulatory interactions. • Author and review CMC sections of regulatory filings (IND/IMPD/BLA). • Evaluate and implement new technologies to enhance upstream development capabilities.
🎯 Requirements
• PhD. in Biochemical Engineering, Cell Biology, Biotechnology, or related field with 10+ years of relevant industry experience; or M.S. with 12+ years. • Proven track record in upstream process development, cell line development, and bioreactor scale-up for biologics is highly preferred. • Hands-on experience with monoclonal antibodies and/or Fc fusion proteins is required. • Strong understanding of formulation development for early-phase biologics. • Experience working with CDMOs and managing outsourced development/manufacturing activities. • Familiarity with regulatory requirements for early- and late-stage biologics development. • Excellent leadership, communication, and project management skills.
🏖️ Benefits
• Health insurance • 401(k) retirement plans • Paid time off • Flexible work arrangements • Professional development opportunities
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