Associate Director, Inflammation Biology

🕒 vor 10 Tagen

🍂 Massachusetts – Remote

🍂 Massachusetts – Remote

💵 $185.000 - $205.000 / Jahr

⏰ Vollzeit

🟠 Senior

👔 Direktor

Jetzt Bewerben

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Apogee Therapeutics

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51 - 200 Mitarbeiter

🧬 Biotechnologie

💊 Pharmazie

💰 €149.000.000 Series B im 2022-12

Biotechnology • Pharmaceuticals

Apogee Therapeutics ist ein biopharmazeutisches Unternehmen im klinischen Stadium, das sich auf die Entwicklung neuartiger Biologika zur Behandlung von Entzündungs- und Immunerkrankungen konzentriert. Das Unternehmen zielt auf bedeutende Märkte in den Bereichen entzündliche und immunologische Erkrankungen ab, wie z. B. atopische Dermatitis, Asthma, chronisch obstruktive Lungenerkrankung, eosinophile Ösophagitis und andere verwandte Zustände. Apogee Therapeutics strebt an, den aktuellen Behandlungsstandard zu verändern, indem es Antikörpertherapeutika vorantreibt, die auf etablierte biologische Mechanismen abzielen und das Potenzial haben, dermatologische, respiratorische und gastroenterologische Probleme zu adressieren. Das Unternehmen ist dazu verpflichtet, ein psychologisch sicheres Arbeitsumfeld zu schaffen, während es innovative Behandlungsoptionen für Menschen mit diesen Erkrankungen priorisiert.

Beschreibung

• Apply deep expertise in biology and pharmacology to provide strategic scientific vision and guide therapeutic I&I biology research across atopic dermatitis, allergic asthma, EoE, and other I&I indications. • Design, develop, and oversee disease-relevant and complex in vitro and ex vivo models using multiple primary human cell types to evaluate the mechanism of action of Apogee antibodies and target biology. • Contribute to authoring and reviewing regulatory submissions and publications. • Manage and coordinate projects (in-house & CRO) to ensure adherence to timelines and goals. • Establish and promote laboratory best practices. • Analyze and interpret complex data from studies to inform on program decisions and effectively communicate outcomes and recommendations to the research group and senior leaders. • Collaborate with scientists across functions to generate high-quality data supporting programs from discovery through development.

🎯 Anforderungen

• Ph.D. degree and a minimum of 8 years of scientific/technical experience. • Broad understanding of I&I disease biology (atopic dermatitis, asthma, and EoE) and underlying disease mechanisms is required and familiarity with inflammatory cytokine/chemokine networks is strongly preferred. • Hands-on expertise developing and validating complex in vitro and ex vivo functional models using disease relevant cell types • Proficiency with analysis of large, cross-platform data sets and assay platforms such as ELISA/MSD, flow cytometry, and cytokine/mediator release assays to characterize and advance therapeutic antibodies and target biology. • Ability to manage multiple projects with competing timelines and shifting priorities simultaneously. • CRO management experience including evaluation of new CROs is desired. • Experience managing and developing junior scientists.

🏖️ Vorteile

• A great culture, grounded in our C.O.R.E. values: Caring, Original, Resilient and Egoless • Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture and company, wear multiple hats, and learn quickly • Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits • We provide competitive time off, including three weeks PTO, two one-week company-wide shutdowns a year and dedicated paid sick leave • Commitment to growing you professionally and providing access to resources to further your development • Apogee offers regular all team, in-person meetings to build relationships and problem solve