Senior Research & Operations Technician

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🕒 April 29

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Orchard Therapeutics

WebsiteLinkedInAll Job Openings

201 - 500 employees

Founded 2016

🧬 Biotechnology

💊 Pharmaceuticals

⚕️ Healthcare Insurance

💰 $150M Post-IPO Equity on 2021-02

Biotechnology • Pharmaceuticals • Healthcare Insurance

Orchard Therapeutics is a biopharmaceutical company pioneering in the development and commercialization of transformative therapies for individuals with severe genetic diseases. The company is focusing on Hematopoietic Stem Cell (HSC) gene therapy, aiming to address unmet medical needs by offering potentially curative treatment options. With a commitment to improving lives significantly impacted by genetic conditions like metachromatic leukodystrophy, Orchard Therapeutics strives to change the treatment paradigm through innovative scientific research and dedication to patients' well-being.

📋 Description

• Senior administrative and technical role responsible for enabling and optimising daily operations and infrastructure of Orchard’s research laboratories to support the strategic goals of the R&D teams • Provide line management of Translational Research Core Technical team, including allocation of assignments, training and development of technical staff • Oversee the coordination of core Molecular Biology, Vector and Analytical activities provided for the Translational Research department to align vector designs with production requirements, working with dedicated technical staff, and where required contribute directly to the delivery of: • Vector Design & Assembly: Generating and validating novel lentiviral vectors for ex vivo or in vivo therapeutic applications, using expertise in molecular biology, CRISPR, PCR, qPCR/ddPCR, molecular cloning, western blotting, and mammalian cell culture. • Production & Optimization: Producing lentivirus, optimising protocols and improving purification processes to improve yield. • Analytical Testing: Performing assays to assess viral titer, potency, transduction efficiency and purity, and developing standardized protocols for vector performance. • Core LLV and Analytical Team Leadership: Providing expertise to support technical research staff, troubleshooting, updating protocols, and ensuring regulatory compliance • Implement rigorous experimental design, statistical analysis, and documentation to ensure reproducibility, traceability, and data integrity. • Oversee the achievement and maintenance of high-quality robust standards of research, and the day-to-day operations of research laboratories, ensuring a safe and organized work environment, efficient workflows and maintenance, training and where required, operation and management of critical research & analytical equipment. • Coordinate with the Facility Management team and IT to ensure smooth lab functioning, adherence to company policies, and support with equipment management, Health & Safety implementation and standards of working practices. • Provide compliance monitoring related to research operations for internal policies, guidelines and regulations governing laboratory operations (HTA, CoBRA etc). • Develop and implement lab workflows, Risk Assessments (PUWERS/ RA for reagents & equipment), SOPs and best practices to support scientific productivity and to lead continuous improvement activities. • Assist with budgetary tracking for the Translational Research Team, collaborating with research scientists and departmental leadership to anticipate operational needs, prepare budget forecasts and allocate resources effectively. • Primary liaison for the Research Team and Facilities Management Team, attending weekly General Lab meetings to foster collaborative relationships between researchers and departments. • Participation in Translational Research departmental meetings to generate ideas for improving efficiency and productivity in laboratory operations, and to develop and implement strategic plans to enhance research performance, including managing space utilisation and resources. • Work closely with Benchling ELN Administrators to support continuous development of the ELN platform for Orchard’s R&D activities including oversight of inventory management, data capture and data integrity. • Any other duties allocated which fall within the general area of the position.

🎯 Requirements

• Experienced molecular/ cellular biologist with strong technical background and analytical abilities to support core technical research staff • Being a team player with a 'can-do' attitude and problem-solving skills is a must • Good understanding of laboratory management issues. • Good understanding of Health & Safety issues relevant to the laboratory including familiarity with BSL-1 and -2 requirements and practices. • Organization, time management, prioritizing and the ability to handle a complex, varied workload • Ability to work efficiently, both independently and as part of a team, with excellent communication, collaboration and influencing skills. • Demonstrable experience of project and laboratory space management. • Good computer skills, experience of working with an ELN is highly desirable • Ability to deal diplomatically but firmly with difficult situations. • Ability to operate in a fast-paced, multi-disciplinary industrial environment, with a customer service mindset • Bachelor’s or Master’s degree in Biology, Life sciences, Biochemistry, Bioengineering, or cell and gene therapy related scientific field, with typically 10+ years of experience in laboratory operations, preferably within biotech or pharma research settings. • Or PhD (or equivalent) in biological sciences or cell and gene therapy related scientific field with experience in laboratory operations, preferably within biotech or pharma research settings.