Manager, R&D Finance

🕒 April 2

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Definium Therapeutics

WebsiteLinkedInAll Job Openings

51 - 200 employees

Founded 2019

🧬 Biotechnology

💊 Pharmaceuticals

Biotechnology • Pharmaceuticals

Definium Therapeutics is a clinical-stage biotechnology company developing precision psychedelic-derived therapeutics for psychiatric and neurodevelopmental disorders. The company focuses on pharmaceutically optimized formulations of lysergide (LSD) and an R-enantiomer of MDMA to treat conditions such as major depressive disorder, generalized anxiety disorder, and core symptoms of autism spectrum disorder, advancing candidates through preclinical and clinical trials with a science-led, evidence-backed approach.

📋 Description

• Prepare and review month-end accruals related to clinical trials, CROs, sites, and other R&D vendors • Maintain recurring journal entries and supporting documentation related to R&D expenses • Apply accounting judgment related to the timing and recognition of clinical trial costs • Prepare quarterly clinical vendor confirmations and audit support schedules • Validate monthly site payments and partner with the Company’s site payment vendor to resolve discrepancies • Review and analyze Clinical Trial Agreements (CTAs), amendments, and site budgets (including Phase 3 trials) for financial accuracy and alignment with forecasts • Track clinical milestones, pass-through costs, and vendor commitments to ensure accurate expense recognition • Perform detailed monthly actual-versus-budget variance analysis for R&D and Clinical Operations spend • Maintain rolling forecasts for clinical trial expenses and support updates based on study progress, amendments, and vendor activity • Assist with the annual budget and periodic forecast processes, including scenario analysis related to clinical timelines and spend variability • Serve as a key finance partner to Clinical Operations and Development teams, translating clinical activity into financial impacts • Coordinate with Legal and Procurement on contract economics, payment terms, and amendments • Collaborate with FP&A to align accounting data with forecasts, cash runway analyses, and management reporting • Assist with the design, execution, and documentation of Sarbanes-Oxley (SOX) controls related to R&D and clinical accounting • Serve as a primary finance contact for internal and external audit requests related to clinical and R&D spend • Identify and implement process improvements to enhance accuracy, efficiency, and scalability of R&D financial processes • Support special projects, system enhancements, and ad hoc analyses as needed • Perform other general accounting duties as assigned

🎯 Requirements

• Bachelor’s degree in Accounting, Finance, or related field; CPA preferred • Minimum of 5 years of progressive accounting or finance experience; public company experience strongly preferred • Experience supporting R&D and/or clinical trial accounting within the life sciences industry strongly preferred • Demonstrated ability to apply accounting judgment in areas involving estimates, accruals, and complex contracts • Experience with NetSuite or other ERP systems; advanced Excel skills required • Strong analytical, organizational, and problem-solving skills • Ability to manage multiple priorities and meet deadlines in a fast-paced environment • Strong communication skills and ability to work effectively with non-finance stakeholders.

🏖️ Benefits

• 100% paid health benefits including Medical, Dental and Vision for you and your dependents • 401(k) program with company match and vesting after the turn of the first month after your start date • Flexible time off • Generous parental leave and some fun fringe perks!