Principal Scientist, Analytical Development, Oligo and Small Molecule

Job not on LinkedIn

🕒 May 20

🇺🇸 United States – Remote

💵 $170k - $190k / year

⏰ Full Time

🔴 Lead

🧬 Research Scientist

🦅 H1B Visa Sponsor

This company has sponsored H1B visas in the past.

👻 Ghost score 55%

What it means: how likely this posting is sitting open without active hiring.How to read it: 60% or higher means we think this is a ghost. Lower scores are less of a worry.How we score it: age, reposts, open roles vs team size, how fast jobs close, and whether pay is listed.Fine print: an estimate from public data, not a judgment of the company. Real jobs can score high, so treat it as a hint, not a fact.

Apply Now

Find Similar Remote Jobs

Set Up Email Alert For New Jobs

📊 Check your resume score for this job

Improve your chances of getting an interview by checking your resume score before you apply.

Upload Resume

Praxis

WebsiteLinkedInAll Job Openings

11 - 50 employees

Founded 2002

🏥 Healthcare

💼 Consulting

📦 Logistics

Healthcare • Consulting • Logistics

Praxis is a company dedicated to connecting patients with meaningful clinical trial opportunities. With a focus on creating customized recruitment programs, Praxis utilizes a variety of specialized tools and extensive experience across various therapeutic areas to ensure they reach the right patients worldwide. Established in 2002, the company emphasizes the importance of patient engagement and utilizes sophisticated data insights to enhance the patient journey in clinical research.

📋 Description

• Serve as Analytical Lead across CMC programs, with primary responsibility for oligonucleotide analytical development and support for small molecule programs • Lead analytical method development, qualification, validation, transfer, and GMP testing across internal teams and external partners • Drive technical troubleshooting, data interpretation, method lifecycle management, and review analytical documentation, including validation reports, stability reports, specifications, and CoAs • Design and implement phase-appropriate analytical control strategies, specifications, and stability programs for oligonucleotide and small molecule drug substances and drug products • Direct and manage CRO/CMO analytical partners to ensure high-quality execution, strong communication, and continuous operational improvement • Collaborate cross-functionally to strengthen CMC operations, improve processes, and establish scalable technical and business practices • Contribute strategic and technical expertise to regulatory filings, commercialization readiness, and product lifecycle management • Advance Praxis’ clinical and commercial pipeline by translating analytical strategies from development into manufacturing across virtual CMOs and external partners

🎯 Requirements

• Advanced degree in Analytical Chemistry or related discipline; PhD preferred, Master’s with significant industry experience considered • 5–7+ years of industry experience • Strong industry experience in analytical development for oligonucleotide drug substances and/or drug products required • Experience supporting small molecule drug substances and solid oral dosage forms strongly preferred • Deep knowledge of analytical techniques relevant to oligonucleotides, including impurity characterization, stability assessment, and GMP control strategies • Strong understanding of US and EU cGMP requirements and analytical best practices for drug substance and drug product development • Experience supporting CMC development across multiple stages, including regulatory submissions, validation, and commercialization activities • Experience managing external CRO/CMO analytical networks and building productive technical partnerships • Strong working knowledge of quality systems, reference standards, stability programs, and compendial testing requirements • Flexibility and willingness to travel as needed

🏖️ Benefits

• 99% of the premium paid for medical, dental and vision plans • Company-paid life insurance • AD&D benefits • Disability benefits • Voluntary plans to personalize coverage • Dollar-for-dollar 401(k) match up to 6% on eligible contributions • Long-term stock incentives • ESPP • Discretionary quarterly bonus • Extremely flexible wellness benefit • Generous PTO • Paid holidays • Company-wide shutdowns