Principal Scientist, Translational Oncology – Single Cell and Spatial Genomics

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🏄 California – Remote

🏄 California – Remote

💵 $171.9k - $214.9k / year

⏰ Full Time

🔴 Lead

🧬 Research Scientist

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Natera

WebsiteLinkedInAll Job Openings

1001 - 5000 employees

Founded 2004

🧬 Biotechnology

⚕️ Healthcare Insurance

💊 Pharmaceuticals

Biotechnology • Healthcare Insurance • Pharmaceuticals

Natera is a global leader in cell-free DNA testing technology, specializing in non-invasive genetic testing and diagnostics. The company's innovative solutions focus on areas such as prenatal screening, cancer detection, and organ transplant monitoring. By using advanced bioinformatics and DNA analysis, Natera provides healthcare professionals and patients with critical information to make more informed medical decisions.

📋 Description

• Drive discovery and translational projects in collaboration with AI and internal research teams with a primary focus on integrating scRNA-seq and spatial biology into Natera’s pipeline. • Collaborate with external translational teams on building single-cell and spatial biology workflows into their early phase clinical studies. • Leverage novel technologies to inform collaborative reverse and forward translation efforts as well as internal target discovery and validation projects. • Design and execute lab-based research programs that bridge clinical observations with mechanistic hypotheses, supporting asset progression and CDP expansion • Lead and contribute to technology area team focused on single cell genomics and spatial omics, building out multiomics capabilities to support foundational models and RWD efforts • Partner with internal and external collaborators to establish, optimize, and deploy cutting-edge platforms for translational applications • Serve as an internal expert and thought leader on emerging genomics technologies relevant to oncology drug discovery and development • Represent translational science on life cycle, RWD, and BioPharma BD teams • Collaborate with Clinical, Biomarker, Discovery, and Regulatory colleagues to shape clinical trial design and biomarker plans • Build and maintain external scientific partnerships and advisory relationships as appropriate • Lead and mentor a team of scientists and contractors, with a strong commitment to career development and scientific growth • Foster a collaborative, high-performance team culture with clear goals and accountability

🎯 Requirements

• Ph.D. in Cancer Biology, Molecular/Cellular Biology, Immunology, Bioengineering, or a closely related field • 6+ years of experience post-Ph.D. in oncology translational research within biotech or pharma, including demonstrated growth into senior or principal scientist roles • Deep scientific expertise in at least one of the following: cancer cell biology, tumor immunology, cell engineering, or neoantigen biology • Hands-on experience with single cell genomics, spatial transcriptomics, or multiomics platforms; experience building or scaling these capabilities in an organizational context is strongly preferred • Strong publication and/or patent record reflecting independent scientific contribution • Demonstrated experience leading cross-functional programs and influencing without authority across Research, Clinical, and Biomarker teams • Prior experience managing and mentoring scientists at multiple career stages • Exceptional scientific communication skills; ability to synthesize complex data and present compellingly to diverse audiences

🏖️ Benefits

• Annual performance incentive bonus • Long-term equity awards • Comprehensive health benefits (medical, dental, vision) • 401(k) with company match • Generous paid time off and company holidays • Additional wellness and work-life benefits