Director, Quantitative Systems Pharmacology

🕒 September 12

🏖️ New Jersey – Remote

🏖️ New Jersey – Remote

💵 $208.2k - $273.2k / year

⏰ Full Time

🔴 Lead

👔 Director

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Eisai US

WebsiteLinkedInAll Job Openings

1001 - 5000 employees

Founded 1995

💊 Pharmaceuticals

🏥 Healthcare

Pharmaceuticals • Healthcare

Eisai US is the United States arm of Eisai Inc. , a global pharmaceutical company focused on researching, developing, manufacturing and commercializing medicines — particularly in neurology (including Alzheimer’s disease) and oncology. With nearly 40 years of U. S. R&D and manufacturing presence, Eisai US runs clinical trials, patient support programs, community involvement and corporate responsibility initiatives under its “human health care” mission, and emphasizes a science-driven pipeline and collaborations to address areas of high medical need.

📋 Description

• Develop, implement, and apply QSP models to understand diseases, pathways, and disease progressions • Evaluate drug candidates and treatment modalities to predict effects and optimize therapeutic strategies • Support clinical introduction, including first-in-human dose selection • Use and improve existing Neurology QSP Platforms and develop new QSP models and platforms as needed • Lead preclinical and early clinical QSP development strategy to support dose selection through mechanistic simulations • Advocate for model-informed drug discovery and development (MIDD) approaches • Provide scientific leadership and present research at scientific conferences • Integrate MIDD strategies into R&D programs to improve efficiency and decision-making • Foster cross-functional collaboration and advance QSP capabilities and modeling tools • Manage expectations and timelines of assigned modeling and simulation work • Use mathematical, computational, and statistical tools to analyze and interpret large, complex datasets • Provide scientific and strategic expertise across therapeutic areas to support translational decision-making

🎯 Requirements

• PhD, MD-PhD and/or PharmD in Bioengineering, Systems Biology, Applied Mathematics, Computational Biology, Pharmacometrics, Chemical Engineering, Pharmaceutical Sciences, or a related quantitative discipline • Deep knowledge of applied mathematical modeling, including numerical methods, ordinary differential equations (ODEs), partial differential equations (PDEs), parameter estimation/optimization, and complex biochemical models • Deep expertise in quantitative systems pharmacology (QSP), mechanistic modeling, systems biology, and translational science • Demonstrated experience applying QSP approaches to support drug discovery and/or clinical development programs with measurable program impact • Strong understanding of pharmacology, physiology, immunology, molecular biology, and disease mechanisms • Ability to learn quickly in new areas of biology and apply quantitative skills to build mechanistically sound QSP models

🏖️ Benefits

• Eligibility to participate in Eisai Inc. Annual Incentive Plan • Eligibility to participate in Eisai Inc. Long Term Incentive Plan • Company employee benefit programs • Certain other benefits may be available for this position