Senior/Staff Bioinformatics Engineer, Clinical Applications

🔥 44 minutes ago

🇺🇸 United States – Remote

💵 $134k - $219.6k / year

⏰ Full Time

🟠 Senior

👷🏻‍♀️ Engineer

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Helix

WebsiteLinkedInAll Job Openings

51 - 200 employees

🏥 Healthcare

🧬 Biotechnology

⚕️ Healthcare Insurance

Healthcare • Biotechnology • Healthcare Insurance

Helix is a company that specializes in integrating genomics into healthcare. By providing access to genetic insights and genomics solutions, Helix empowers health systems, public health, and life sciences companies to incorporate genomics into their operations. This enhances medical research, diagnosis, treatment, and prevention, enabling more personalized and effective healthcare. Helix collaborates with partners such as Sanford Health to expand genomics initiatives, making genomics actionable and accessible, thereby improving preventive care and patient outcomes. Helix's services are designed to support providers, patients, and health systems in navigating the genetic testing process, offering comprehensive solutions across the genomics landscape.

📋 Description

• Productionize curation workflows supporting classical and modern AI/ML approaches to variant classification • Automate evidence integration from ClinVar, gnomAD, PubMed, and other sources • Collaborate with scientists, product, and clinical stakeholders to meet scientific and product requirements • Direct AI coding agents to accelerate curation pipeline development • Validate correctness, security, and architectural fit before deployment • At Senior level, own defined projects end to end and make technical decisions within agreed priorities and architecture • At Staff level, frame ambiguous problems, set technical direction, and make architecture and prioritisation decisions across the product area • Participate in onboarding, training, project ownership, and OKR development during the first 90 days

🎯 Requirements

• Bachelor's degree in Science or related field with 7+ years (Senior) or 9+ years (Staff) of professional software development experience, or a Master's or Ph.D. with 3+ years (Senior) or 5+ years (Staff) of professional software development experience • Advanced proficiency in production-quality Python, relational databases, and cloud platforms such as AWS • Experience productionizing and scaling AI/ML software, especially agentic systems built with frameworks such as LangChain or LangGraph • Experience collaborating with scientists to integrate bioinformatics/NGS tools and databases into production workflows • Strong judgment evaluating AI-generated code and pipeline logic for correctness, security, and maintainability before production • Experience in clinical genomics, such as ACMG guidelines, clinical diagnostics, or HPO terms is a plus • Experience developing regulated software, such as software as a medical device, is a plus • At Staff level, mentoring or managing others, or interest in developing as a people leader, is a plus

🏖️ Benefits

• Comprehensive Health Insurance with Date of Hire eligibility • Above average employer paid premium coverage • 12 weeks Helix Paid Parental Leave option • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire • Comprehensive Well-Being Benefits • Flexible PTO • Remote options for many roles and a home office stipend • Equity • Discretionary annual bonus: 15% (Staff)/ 10% (Senior) of annual salary

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