Executive Director – Preclinical and Translational Sciences

🕒 April 29

🇺🇸 United States – Remote

💵 $270k - $342k / year

⏰ Full Time

🔴 Lead

🌎 Translator / Interpreter

🦅 H1B Visa Sponsor

This company has sponsored H1B visas in the past.

Apply Now

Find Similar Remote Jobs

Receive Emails For Remote Jobs

📊 Check your resume score for this job

Improve your chances of getting an interview by checking your resume score before you apply.

Upload Resume

4D Molecular Therapeutics

WebsiteLinkedInAll Job Openings

51 - 200 employees

4DMT is a clinical stage biopharma company inventing and developing innovative products to unlock the full potential of genetic medicine to treat large market and rare diseases. Our vector discovery platform Therapeutic Vector Evolution harnesses the power of directed evolution, a Nobel Prize-winning technology, with approximately one billion synthetic AAV capsid-derived sequences to invent customized and evolved vectors with improved therapeutic profiles compared to wild-type vectors. Our product design, development and manufacturing engine empowers us to efficiently create our valuable and diverse product pipeline. This combination of bold innovation and relentless execution gives 4DMT the capability to revolutionize genetic medicines and to strive for potential curative therapies. We have built a deep portfolio of genetic medicine product candidates, with five product candidates in clinical trials for seven patient populations.

📋 Description

• Set, communicate and drive strategy for Translational products in alignment with the broader organization of 4DMT • Prioritize and allocate resources, both within Translational and beyond, to meet portfolio needs • Lead the decision-making process with other relevant functional group heads regarding indications, targets and products’ progression from concept, design, preclinical development and Phase 1-2 clinical testing. • Provide input on scientific strategy from the earliest consideration of new targets through development, including risk, scientific challenges, timing of resource investment and development of go/no go decisions • Direct and coordinate the implementation of preclinical study programs for pharmacology studies in support of the lead to candidate optimization process • Design, implement and write-up comprehensive series of pharmacology studies to address preclinical exposure, develop pharmacokinetics and pharmacodynamics profiles and generate GLP toxicology and bio-distribution packages suitable for supporting IND filings • Manage budgets and headcounts • Design, implement and manage externally facing in vivo studies with CROs and academic centers, including drafting proposals, budget oversight and managing deliverables • Resource planning; hiring and mentoring talents; building the team and technical capabilities • Build collaborations with relevant functions at 4DMT; represent own function at the corporate level and externally • Provide direct hands-on responsibility for all Translational interactions as well as grant writing and management with rare disease advocacy groups • Participate on project teams and direct activities to ensure regulatory compliance of pre-clinical and clinical research activities • Support regulatory affairs in their preparation, review and submission of necessary pre-clinical and clinical regulatory information to regulatory agencies worldwide • Contribute to defining of clear human POC study outcome criteria for decision-making on new product candidates • Contribute senior level expertise to alliance, business development, due diligence exercises with external entities and licensing meetings as well as other critical external interfaces such as public health regulatory bodies • Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time

🎯 Requirements

• PhD, MD/PhD, MD or equivalent • 12+ years of relevant preclinical and/or translational sciences experience within the Biotech or similar industry • 4+ years of management experience or other specific work experience • Experience with preclinical, translational, and clinical R&D • Prior leadership position/s within the pharmaceutical/biotech industry or academic medical centers, with a significant history of research and translational experience • Reputation for inspiring a culture of continuous improvement, innovation and quality, leading and mentoring at the highest level of achievement. • Team leadership skills and experience in a matrixed organization • Strong communication skills both written and oral with demonstrated ability to present ideas, information, and data effectively via one-on-one discussions, team meetings, and presentations to executive leadership • Excellent time management skills and the ability to adapt to changing priorities • Self-starter who proactively establishes effective working relationships and builds partnerships with other disciplines. • Adaptability, flexibility, independence and resourcefulness; as an active participant in a vibrant small company culture, rolls up sleeves and manages multiple activities in parallel. • Ability to proactively identify challenges; possesses strategic foresight and implements appropriate courses of action • Excellent verbal and written communication skills.

🏖️ Benefits

• Health insurance • Retirement plans • Flexible work arrangements • Professional development opportunities