Clinical Variant Scientist I

Job not on LinkedIn

🔥 5 minutes ago

🇺🇸 United States – Remote

💵 $79.6k - $119.4k / year

⏰ Full Time

🟡 Mid-level

🟠 Senior

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ARUP Laboratories

WebsiteLinkedInAll Job Openings

1001 - 5000 employees

Founded 1984

💼 Consulting

🏥 Healthcare

🧬 Biotechnology

Consulting • Healthcare • Biotechnology

ARUP Laboratories is a national, academic, nonprofit reference laboratory that provides comprehensive diagnostic testing, specialized genetic and molecular assays, and clinical decision support to healthcare systems, clinicians, and researchers. It offers clinical and pharmaceutical research services, laboratory consulting and analytics, and educational resources including continuing education and expert guidance. ARUP is accredited by CAP, CLIA, and ISO 15189 and collaborates with academic partners to advance diagnostic innovation and precision medicine.

📋 Description

• Interpret and classify genetic variants identified through clinical testing • Review genomic data from oncology NGS tests and perform somatic variant interpretation • Evaluate data quality from next-generation sequencing/massively parallel sequencing platforms • Research clinical significance using medical literature, external databases, and computational prediction software • Collect and integrate data related to cancer biology and/or heritable disorders and potential clinical-care impact • Assess plausibility of laboratory results using patient demographics and clinical symptoms • Draft accurate and consistent clinical reports for medical director review • Collaborate with laboratory teams, genetic counselors, medical directors, scientists, staff, directors, and management • Troubleshoot unique scenarios and optimize clinical workflows and processes • Contribute to quality assurance, standard operating procedures, and best practices for variant interpretation • Maintain compliance with regulatory standards, policies, procedures, and record keeping • Accept, resolve, and assist with resolution of problems • Perform peer assessments as a Qualified Observer after two years of experience • Maintain current knowledge of genomic research and guidelines • Spend approximately 85–95% of time analyzing clinical cases

🎯 Requirements

• Master's degree or better in Biological Sciences or related field required • Ph.D. in genetics, molecular biology, or related biological science OR Master's degree in genetic counseling, genetics, molecular biology, or related biological science and 4 years of relevant clinical work experience • Relevant clinical work experience including writing, reading, and proofreading molecular genetics clinical reports • Experience critically reviewing scientific and/or medical literature • Experience with germline and/or somatic variant interpretation based on professional guidelines such as ACMG, AMP, and ClinGen preferred • Experience reviewing and analyzing NGS/MPS and/or genomic microarray data preferred • Experience utilizing online human genomic databases and genomic annotation preferred • Familiarity with NGS/MPS laboratory and bioinformatics processes preferred • In-depth knowledge of genetic mechanisms of disease relevant to somatic and/or germline variation preferred • Strong written, verbal, and interpersonal communication skills preferred • Ability to use standard nomenclature and professional standard classification guidelines • Ability to evaluate clinical laboratory data quality • Understanding of protein structure and function, RNA splicing, gene regulation, genetic mechanisms of disease, and sequence variants • Understanding of experimental methods, data analysis methods, and inferences for single-gene and high-throughput analyses • Ability to perform highly accurate data entry, recognize inconsistencies, and initiate resolution • Ability to correlate laboratory results with patient demographics and clinical symptoms • Ability to comply with regulatory policies, procedures, and record-keeping requirements • Ability to use personal protective equipment in a biohazard laboratory environment in accordance with CDC and OSHA regulations • Must be able to communicate effectively and perform fine motor, typing, visual, color vision, stooping, reaching, and sedentary work activities

🏖️ Benefits

• Fully remote position • Professional growth and continuous development • Diversity-focused work environment • Flexible schedule determined by operational needs • Monday–Friday schedule, 40 hours per week • Occasional weekends may be included to meet clinical reporting requirements