Principal Scientist – Translational Medicine

🔥 15 hours ago

🏄 California, Massachusetts – Remote

🏄 California – Remote 🍂 Massachusetts – Remote

💵 $190k - $210k / year

⏰ Full Time

🟠 Senior

🧬 Research Scientist

👻 Ghost score 3%

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GondolaBio

WebsiteLinkedInAll Job Openings

11 - 50 employees

Founded 2024

🏥 Healthcare

💼 Consulting

🏭 Manufacturing

💰 $300M Venture Round - GondolaBio on 2024-08

Healthcare • Consulting • Manufacturing

GondolaBio is a clinical-stage biopharmaceutical company launched in 2024 and affiliated with BridgeBio Pharma, focused on developing breakthrough therapeutics for patients with genetic diseases. The company uses a lean, decentralized approach to accelerate early-stage research and development across multiple modalities (including small molecules and oligonucleotide therapies) and is building a diverse pipeline targeting rare and underserved genetic conditions such as EPP/XLP with its lead program PORT-77. GondolaBio centers patient needs and aims to bring disease-modifying treatments more quickly to populations lacking approved therapies.

📋 Description

• Partner with discovery and preclinical teams to identify and prioritize translational biomarkers • Translate preclinical findings into clinical biomarker strategies, including pharmacodynamic, target engagement, and disease-relevant endpoints • Lead development, qualification, and validation of biomarker assays • Oversee assay transfer, validation, and execution at CROs and external laboratories • Ensure assays are implemented in CLIA-compliant or equivalent environments when appropriate • Partner with Clinical Operations to design sample collection schedules, lab manuals, and logistics workflows • Coordinate with clinical sites and vendors to ensure sample integrity and operational feasibility • Integrate biomarker data with clinical, PK/PD, and safety datasets to generate decision-ready insights • Contribute to clinical protocol design, regulatory documentation, and cross-functional decision-making • Serve as a key partner across discovery, clinical development, clinical operations, regulatory, and data science teams • Drive clinical biomarker strategy and execution across early neuroscience clinical programs • Translate discovery-stage hypotheses into clinically actionable biomarker approaches for global studies

🎯 Requirements

• PhD or equivalent in a relevant discipline • 8+ years of experience in translational medicine, biomarker sciences, or clinical bioanalysis • Experience managing biomarker strategies in global clinical studies and working with CROs • Understanding of biomarker assay platforms and bioanalytical validation principles • Experience working in or with CLIA or regulated laboratory environments • Experience in neurology or CNS disorders preferred but not required • Experience with intrathecal or CNS-targeted therapeutics preferred • Familiarity with CSF biomarker workflows or neurophysiological biomarkers such as EEG preferred • Experience contributing to regulatory submissions preferred • Ability to operate cross-functionally across discovery, clinical development, and clinical operations • Expertise in biomarker strategy, assay development, and clinical implementation • Experience driving work through CROs and external partners

🏖️ Benefits

• Patient Days with opportunities to hear directly from patients • Culture inspired by company values • Decentralized operating model • Ownership of program and career vision • Collaborative, fast-paced, data-driven environment • Access to learning and development resources • Robust and market-competitive compensation and benefits package • Performance bonus • Equity • Health and welfare programs • Retirement programs • Flexible PTO • Rapid career advancement for strong performers • Potential to work on multiple programs across therapeutic areas • Partnerships with leading institutions