Principal AI Systems Engineer

Job not on LinkedIn

🕒 June 1

🇺🇸 United States – Remote

💵 $175k - $200k / year

⏰ Full Time

🔴 Lead

⚙️ Systems Engineer

👻 Ghost score 26%

What it means: how likely this posting is sitting open without active hiring.How to read it: 60% or higher means we think this is a ghost. Lower scores are less of a worry.How we score it: age, reposts, open roles vs team size, how fast jobs close, and whether pay is listed.Fine print: an estimate from public data, not a judgment of the company. Real jobs can score high, so treat it as a hint, not a fact.

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Iovance Biotherapeutics, Inc.

WebsiteLinkedInAll Job Openings

501 - 1000 employees

Founded 2014

🏥 Healthcare

🧬 Biotechnology

💊 Pharmaceuticals

Healthcare • Biotechnology • Pharmaceuticals

Iovance Biotherapeutics, Inc. is pioneering a transformational approach to treating cancer by harnessing the human immune system's ability to recognize and attack diverse cancer cells in each patient. The company focuses on T-cell-based immunotherapy, specifically Tumor Infiltrating Lymphocyte (TIL) therapy, which involves reinvigorating a patient’s TILs to fight cancer. Iovance's TIL therapy is being investigated in clinical trials across multiple advanced solid tumor cancers. Additionally, the company is advancing genetically modified TIL therapies and exploring potential applications of PBL (peripheral blood lymphocyte) therapy for blood cancers. As a leader in cell therapy, Iovance owns a state-of-the-art Cell Therapy Center in Philadelphia for manufacturing their therapies using proprietary GMP. The company is at the forefront of developing personalized and patient-specific cancer treatments.

📋 Description

• Design, build, and ship AI systems against the approved Iovance AI roadmap • Own architecture, retrieval pipelines, prompts, evaluation, integrations, and deployment for assigned use cases • Implement production-grade RAG systems on AWS infrastructure using S3, Redshift, and Bedrock • Build and operate evaluation harnesses with held-out test sets, accuracy and grounding metrics, hallucination detection, adversarial inputs, and regression testing • Design integrations between AI systems and enterprise systems using MCP, APIs, and event-driven patterns • Maintain LLM security controls, including guardrails, prompt-injection and jailbreak defenses, sensitive-data redaction, content moderation, and abuse monitoring • Design, develop, deploy, and maintain AI agents for regulated life-sciences use cases • Establish version control, CI/CD, environment separation, and reproducible-build practices • Evaluate AI vendors, tools, and foundation models and provide build-versus-buy recommendations • Implement audit logging, access management, change control, model registry, performance monitoring, and incident detection • Author architecture diagrams, data-flow diagrams, evaluation reports, runbooks, and validation deliverables • Contribute to the Iovance AI Validation Playbook • Mentor junior engineers and provide technical recommendations on AI tooling, models, and engineering practices

🎯 Requirements

• 10+ years of progressive software and/or AI/ML engineering experience, with the most recent 1+ years dedicated primarily to LLM-based application development • Demonstrated track record of shipping production AI systems that real users depend on • Deep, hands-on production experience with Retrieval-Augmented Generation (RAG), including chunking strategies, embedding models, vector stores, retrieval and reranking, and grounding • Working production experience with Model Context Protocol (MCP) or equivalent agent/tool integration patterns • Practical working experience across multiple frontier model families, such as Anthropic Claude, OpenAI GPT, Google Gemini, and leading open-weight models • Strong production Python skills and ideally one other programming language • Experience with modern Agile delivery, Git, CI/CD, containerization, cloud platforms, preferably AWS, and MLOps tooling and practices • Working production experience with AWS S3, Redshift, Bedrock, and IAM is strongly preferred • Working knowledge of enterprise search and retrieval services such as OpenSearch, Elasticsearch, or equivalent, including hybrid vector and lexical/BM25 retrieval patterns • Ability to remain stationary standing or sitting for prolonged periods • Ability to move inside an office and occasionally exert up to 10 pounds of force • Visual acuity for data analysis, computer-screen viewing, and extensive reading • Ability to perform repetitive wrist, hand, and finger movements • Ability to communicate with others to exchange information • Clear and conceptual thinking ability; excellent judgment, troubleshooting, problem-solving, analysis, and discretion • Ability to handle work-related stress, multiple priorities, and deadlines