Scientist/Sr. Scientist, Oligo Biology – In Vitro

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🏄 California – Remote

🏄 California – Remote

💵 $115k - $175k / year

⏰ Full Time

🟠 Senior

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Korsana Biosciences

WebsiteLinkedInAll Job Openings

2 - 10 employees

🧬 Biotechnology

💊 Pharmaceuticals

Biotechnology • Pharmaceuticals

Korsana Biosciences is a biotechnology company discovering and developing novel, precision-engineered therapeutics to reduce the burden of neurodegenerative diseases by improving delivery of drugs to the central nervous system. The company has developed a blood-brain barrier (BBB)-penetrant shuttle platform called THETA™ (in partnership with Paragon Therapeutics) to enhance CNS exposure of investigational therapies and is advancing programs targeting Alzheimer’s disease and other neurodegenerative conditions. Korsana maintains a clinical-stage pipeline (e. g. , KRSA-028), engages in industry partnerships, and recently announced a merger agreement with Cyclerion Therapeutics to further its development efforts.

📋 Description

• Design molecular and cellular biology experiments in close collaboration with internal bioinformatics and chemistry teams to support robust in vitro and in vivo screening campaigns. • Manage external CROs, including experimental design, priority setting, technical oversight, data review, timeline management, and proactive troubleshooting to ensure high-quality, timely project execution. • Design and optimize siRNAs, ASOs, PMOs, and other novel nucleotide modalities to enhance therapeutic profiles. • Generate and interpret structure-activity relationships (SAR) to guide lead optimization and candidate selection. • Maintain thorough technical documentation using Electronic Lab Notebooks (ELNs) and effectively communicate experimental strategies, results, and recommendations to multidisciplinary scientific audiences. • Actively evaluate emerging technologies and scientific literature to identify innovative approaches that enhance oligonucleotide potency, extrahepatic delivery, durability, and safety.

🎯 Requirements

• Ph.D. in biology, pharmaceutical sciences, or related discipline with 0-6 years of relevant industry experience, OR M.S. with 2-8 years of industry experience in oligonucleotide therapeutic development. • Deep understanding of siRNA and ASO design principles, cellular mechanisms of action, and chemical modification strategies. • Familiarity with state-of-the-art oligonucleotide delivery technologies, including GalNAc conjugates, lipid conjugates, peptide/antibody-oligonucleotide conjugates (AOCs), or other targeted delivery methods. • Hands-on experience with mammalian cell culture, diverse transfection methodologies.

🏖️ Benefits

• Eligible for target annual bonus • Equity-based compensation • Participation in the company’s benefit programs