
201 - 500 employees
Founded 1996
💊 Pharmaceuticals
🧬 Biotechnology
☁️ SaaS
💰 Grant - Simulations Plus on 2024-11
Pharmaceuticals • Biotechnology • SaaS
Simulations Plus, Inc. is a science-driven software and consulting company that provides mechanistic modeling, AI-enabled workflows, and expert services to support model‑informed drug development (MIDD) across discovery, development, clinical operations, and commercialization. Its product suite includes GastroPlus (PBPK/PBBM), MonolixSuite (pharmacometrics), ADMET Predictor (ML for ADMET), DILIsym (quantitative systems toxicology), Thales (QSP), and Pro‑ficiency (learning/simulation), and the company offers consulting, training, regulatory strategy support, and bundled solution packages. Simulations Plus emphasizes mechanistic and AI-enabled tools for ADMET prediction, PBPK, pharmacometrics, QSP/QST and serves pharmaceutical and biotech clients (noting ~30+ years in business, ~280+ clients and use by 19 of the top 20 pharma companies).
🔥 4 minutes ago
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201 - 500 employees
Founded 1996
💊 Pharmaceuticals
🧬 Biotechnology
☁️ SaaS
💰 Grant - Simulations Plus on 2024-11
Pharmaceuticals • Biotechnology • SaaS
Simulations Plus, Inc. is a science-driven software and consulting company that provides mechanistic modeling, AI-enabled workflows, and expert services to support model‑informed drug development (MIDD) across discovery, development, clinical operations, and commercialization. Its product suite includes GastroPlus (PBPK/PBBM), MonolixSuite (pharmacometrics), ADMET Predictor (ML for ADMET), DILIsym (quantitative systems toxicology), Thales (QSP), and Pro‑ficiency (learning/simulation), and the company offers consulting, training, regulatory strategy support, and bundled solution packages. Simulations Plus emphasizes mechanistic and AI-enabled tools for ADMET prediction, PBPK, pharmacometrics, QSP/QST and serves pharmaceutical and biotech clients (noting ~30+ years in business, ~280+ clients and use by 19 of the top 20 pharma companies).
• Design, write, test, and use computer code to build and maintain sub-models representing cellular, molecular, and/or biochemical processes • Represent compound pharmacodynamics and/or mechanism of action, translating laboratory data into model parameters and curating clinical data for calibration and validation • Learn and utilize company agentic AI solutions for technical work • Contribute to successful completion of consulting project goals • Contribute to R&D efforts, including license-ready model updates and development of QST models of liver injury • Combine systems pharmacology modeling, software code development, maintenance, and project management • Develop plans and deliverables consistent with sponsor service agreements • Schedule meetings with internal and external collaborators • Prepare presentations and reports, conduct scientific review, and respond to feedback • Lead consulting projects when qualified and available • Participate in preparation and review of joint manuscripts • Manage project effort within contracted resources • Publish scientific work, including documentation, figures, and correspondence with editors and peer reviewers • Train others on QSP/QST and related models • Perform other duties as assigned
• 2+ years of QSP/QST modeling experience or equivalent skill sets • Proficiency in mathematics, dynamic systems, and drug development • General knowledge of relevant therapeutic areas, clinical endpoints, and underlying cell and molecular biology and/or biochemistry • Experience with MATLAB, THALES, Julia, SimBiology, Monolix, GastroPlus™, and/or C++ programming • Experience with PBPK, PK, popPK, and/or PKPD modeling • Basic familiarity with large-language models and agentic AI • Understanding of how to apply modeling and simulation for maximum impact • Strong verbal and written communication skills • Ability to multitask and good organizational skills • Self-motivated with ability to work with minimal supervision • Occasional travel for conferences, meetings, and training • Master’s degree in pharmaceutical science, biomedical engineering, or related field required • PhD in pharmaceutical science, biomedical engineering, or related field preferred
• Fully remote work • Flexible schedules • Generous vacation policy • Affordable health coverage • Annual bonus • Employee well-being programs • Opportunities to publish work in scientific journals • Professional training and development opportunities
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