Senior Manager, Translational Modeling

🕒 2 days ago

🌲 North Carolina – Remote

🌲 North Carolina – Remote

⏰ Full Time

🟠 Senior

🌎 Translator / Interpreter

Apply Now

Find Similar Remote Jobs

Receive Emails For Remote Jobs

📊 Check your resume score for this job

Improve your chances of getting an interview by checking your resume score before you apply.

Upload Resume

BioCryst Pharmaceuticals, Inc.

WebsiteLinkedInAll Job Openings

501 - 1000 employees

🧬 Biotechnology

💊 Pharmaceuticals

💰 $450M Post-IPO Debt - BioCryst Pharmaceuticals on 2023-04

Biotechnology • Pharmaceuticals

BioCryst Pharmaceuticals, Inc. is a global biotechnology company focused on the discovery, development, and commercialization of novel oral small-molecule and protein therapeutics for rare diseases, notably hereditary angioedema (HAE). Founded in 1986, BioCryst uses structure-guided drug design, medicinal chemistry, and advanced technologies to develop first-in-class or best-in-class medicines, and works closely with patients, advocacy groups, and global partners to bring treatments to market.

📋 Description

• Provide expert mathematical modeling to lead development of mechanistic modeling strategy for drug discovery, and early development through clinical with a strong focus on biologics, and protein therapeutics. • Lead the design, implementation, calibration, validation, and documentation of mechanistic modeling approaches to address MIDD questions across programs. • Develops PBPK, PK/PD, QSP models, and mechanistic pathway models, ensuring scientific rigor and consistency. • Drive translational modeling strategies to support discovery and early development decision-making. • Integrate data from multiple sources (in vitro, in vivo, and emerging datasets) to build robust translational models. • Collaborate closely with cross-functional stakeholders (DMPK, toxicology, bioanalytical, biology, clinical pharmacology) to ensure alignment and impact of modeling approaches. • Present modeling strategies, results, and recommendations to cross-functional teams and guide program discussions. • Guide study design and data generation strategies to maximize translational value. • Author and review modeling components of regulatory documents (e.g., IND-enabling packages, briefing materials) and support regulatory interactions as needed. • Promote and implement best practices in modeling workflows and ensure high-quality, reproducible outputs. • Evaluate and apply emerging methodologies, including AI/ML, to enhance modeling capabilities. • Coordinate modeling deliverables across assigned programs and ensure timelines and quality expectations are met. • Contribute to external scientific engagement through publications and conference presentations.

🎯 Requirements

• PhD in systems biology, chemical, mechanical or biomedical engineering, biochemistry, physics, applied mathematics, bioinformatics, or scientific computing. • Minimum of 5 years of experience in pharma/biotech with significant experience in translational modeling. • Strong proficiency in scientific computing and programming, with strong preference for Matlab/SimBiology. • Extensive experience developing and applying mechanism-based mathematical models of biological systems. • Proven experience with MIDD approaches in particular with PBPK and QSP modeling workflows across multiple programs with a track record of translational modeling impacting program cadence/success. • Strong understanding of translational science and drug development from discovery through early development and related disciplines (pharmacometrics, pharmacology, pharmacodynamics, toxicology, bioanalytics). • Demonstrated ability to contribute to and guide program-level decision-making using modeling and simulation approaches. • Track-record of utilizing M&S to guide experimental design specific to modality-driven target hypotheses. • Strong analytical, problem-solving, and data interpretation skills. • Excellent written and oral communication skills with the ability to influence cross-functional teams.

🏖️ Benefits

• Health insurance • 401(k) matching • Flexible work hours • Paid time off • Professional development opportunities