Principal – AD Medicinal Chemist

🔥 0 minutes ago

🇺🇸 United States – Remote

⏰ Full Time

🔴 Lead

👻 Ghost score 12%

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Deep Origin

WebsiteLinkedInAll Job Openings

11 - 50 employees

🏥 Healthcare

💼 Consulting

📦 Logistics

Healthcare • Consulting • Logistics

Deep Origin is a cutting-edge company focused on accelerating research and development in the life sciences through its innovative platform and tools. It offers a molecular simulation toolkit and R&D platform that harness the power of artificial intelligence and seamless data management. Deep Origin's solutions are designed to help scientists tackle complex biological and disease-related challenges by providing tools for data analysis, molecular simulation, and drug discovery. The company aims to revolutionize computational biology and simulate biological processes to aid in discovering new therapies and understanding diseases. Deep Origin's offerings include AI-driven analysis assistants, high-performance workstations, and virtual drug screening capabilities, making it a powerful ally for interdisciplinary scientific research and development.

📋 Description

• Lead and advance small molecule drug discovery programs from early hit identification through IND-enabling studies • Direct work completed at contract research organizations (CROs) • Propose and independently drive medicinal chemistry strategies from hit identification through lead optimization to development candidate selection • Lead chemistry efforts within cross-functional teams including bench biologists, DMPK, non-clinical toxicology, computational science, and ML engineering • Design, prioritize, and guide synthesis of novel compounds using structure-based and ligand-based approaches • Optimize potency, selectivity, pharmacokinetics, and developability • Interpret and integrate SAR, structural biology, DMPK, pharmacology, and safety data • Integrate AI-driven and computational modeling insights into compound design strategies • Mentor internal chemists and external collaborators • Manage external CRO partnerships for high-quality and timely chemistry delivery • Communicate program strategy, data, risks, and recommendations to senior leadership • Author and contribute to patent strategies and applications, scientific publications, and internal reports

🎯 Requirements

• PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry • Proven track record of advancing drug discovery programs through key milestones (Hit-to-Lead and Lead Optimization) • Deep expertise in synthetic organic chemistry, including modern methods and reaction mechanisms • Strong experience in structure-based and ligand-based drug design • Demonstrated ability to optimize compounds for potency, selectivity, and DMPK/safety properties • High level of creativity, productivity, and independent problem-solving ability • Experience managing external CROs and collaborating across disciplines • Excellent communication skills with the ability to clearly present complex scientific concepts • Experience working on small molecule degraders, proximity-inducing chemistry (Nice-to-Have) • Experience integrating computational chemistry, machine learning, or AI-driven design into medicinal chemistry workflows (Nice-to-Have) • Background in predictive toxicology or ADMET modeling (Nice-to-Have) • Prior experience contributing to IND-enabling studies or clinical candidate selection (Nice-to-Have) • Familiarity with modern data science tools and cheminformatics platforms (Nice-to-Have) • Applicants must be authorized to work for any employer in the U.S.; employment visa sponsorship is unavailable

🏖️ Benefits

• Competitive compensation aligned with market benchmarks • Equity participation reflecting long-term impact • Remote-friendly culture across Europe and the U.S • Flexible working structure with cross-time-zone collaboration