Director, Medicinal Chemistry

🔥 17 minutes ago

🇺🇸 United States – Remote

💵 $153k - $290.4k / year

⏰ Full Time

🔴 Lead

👔 Director

👻 Ghost score 0%

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Eli Lilly and Company

WebsiteLinkedInAll Job Openings

10,000+ employees

💊 Pharmaceuticals

🏥 Healthcare

🧬 Biotechnology

💰 $6.5M Post-IPO Debt - Eli Lilly on 2024-02

Pharmaceuticals • Healthcare • Biotechnology

Eli Lilly and Company is a multinational pharmaceutical company that researches, develops, manufactures, and markets prescription medicines across multiple therapeutic areas including diabetes, oncology, immunology, neuroscience, and pain. Headquartered in Indianapolis, Indiana, Lilly is known for its extensive R&D, clinical development, and global commercialization of biologic and small-molecule drugs. The company focuses on drug discovery, clinical trials, regulatory approvals, and large-scale pharmaceutical manufacturing and distribution.

📋 Description

• Lead and manage internal chemistry resources and dedicated synthetic chemistry teams within CROs • Set priorities, resolve synthetic challenges, and direct groups toward IND-ready candidate molecules • Serve as chemistry leader within the broader multidisciplinary project team • Build effective working relationships with colleagues, partners, consultants, and CROs • Design new molecules addressing the target product profile and establish new intellectual property • Progress projects toward time-based goals • Develop chemistry strategies that secure robust intellectual property positions • Analyze SAR from weekly pharmacology and ADME data to identify opportunities for improved molecules • Translate data into tractable designs for molecules with drug-like properties • Monitor competitor activities and current medicinal chemistry developments • Communicate regularly with synthetic teams and maximize throughput of test compounds • Utilize in-house structure-based drug design knowledge and compound property computational predictive tools • Present data and articulate next steps at chemistry-focused and cross-functional team meetings and ad hoc face-to-face meetings • Use SAR and literature precedent to defend proposed designs and consider alternative suggestions • Communicate ideas clearly and professionally with project teams and senior management

🎯 Requirements

• BS/MS Chemistry; PhD strongly preferred • 10+ years designing small molecules as a medicinal chemistry team leader within a biotech and/or pharmaceutical company • Expert command of synthetic chemistry and medicinal chemistry principles • Solid working knowledge of pharmacology, ADME, pharmaceutical sciences, IP protection, and candidate selection criteria • Experience working on CNS targets and across all stages of discovery, from hit-to-lead and lead optimization through IND-ready candidates • Proven ability to lead and motivate teams, including remote and virtual teams, toward aggressive timelines • Strong independent scientific judgment, interpersonal, and leadership skills • Experience managing outsourced chemistry teams • Adaptive problem-solving ability • Technical depth and a growth mindset • Curiosity and drive for self-identified innovation, especially exploration of artificial intelligence and digital tools

🏖️ Benefits

• Company bonus depending in part on company and individual performance • Company-sponsored 401(k) • Pension • Vacation benefits • Medical, dental, vision, and prescription drug benefits • Flexible benefits, including healthcare and/or dependent day care flexible spending accounts • Life insurance and death benefits • Time off and leave of absence benefits • Well-being benefits, including employee assistance program, fitness benefits, and employee clubs and activities • Remote work arrangement • Occasional travel