Associate Director, Medicinal Chemistry

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MapLight Therapeutics, Inc.

WebsiteLinkedInAll Job Openings

11 - 50 employees

🧬 Biotechnology

⚕️ Healthcare Insurance

💊 Pharmaceuticals

Biotechnology • Healthcare Insurance • Pharmaceuticals

MapLight Therapeutics, Inc. is a biotechnology company dedicated to transforming the treatment of brain disorders, including conditions such as schizophrenia, Alzheimer’s disease, and autism spectrum disorder. They leverage advanced technologies like optogenetics and transcriptomics to identify specific neural circuits involved in these disorders, aiming to develop targeted therapeutics with the potential to significantly improve patient outcomes. Their innovative discovery platform supports a robust pipeline of clinical and preclinical trials focused on addressing significant unmet medical needs in central nervous system conditions.

📋 Description

• Co-lead, or lead, preclinical medicinal chemistry programs from hit to candidate nomination. • Design and execute successful medicinal chemistry strategies to meet project and corporate goals. • Conduct multi-parameter optimization to deliver orally bioavailable, brain-penetrant candidates without secondary pharmacology, ADME, or safety concerns of initial hits. • Apply structure-based drug design principles utilizing in-house resources and external computational partners. • Manage chemistry and tiered screening cascade at external contract research organizations (CROs). This includes maintaining a good relationship, overseeing synthesis or experimental plans, project tracking, evaluation of results, and assisting in troubleshooting. May require assessment of analytical data including NMR, LCMS, HPLC, UV-VIS, and DSC. • Apply previous experience with successful hit finding strategies to find novel chemical equity, including scaffold-hopping approaches. • Coordinate with in-house drug discovery team to ensure compounds are distributed in support of other disciplines. • Provide regular project updates to Leadership and Project Teams that include relevant updates. May include in-depth SAR, ADME, and PK analyses. • Co-lead, or lead, patent strategy to protect existing or novel chemical matter with Maplight legal partners, when appropriate. • You can participate and work effectively with multiple cross-functional teams. • You have strong interpersonal skills and understand relationships are key to being successful. • You are a leader. Teams love working with you, and you are someone who takes pride in mentoring and supporting the careers of others. • You’re a team player who is willing to roll-up your sleeves and get the job done.

🎯 Requirements

• PhD in Chemistry or Medicinal Chemistry with 10+ years’, or BS/MS 15+ years’, pharmaceutical experience successfully (co)leading preclinical drug discovery programs. • Contemporary knowledge of Medicinal Chemistry concepts with strong working knowledge of computational chemistry, biology, pharmacology, drug metabolism, and pharmacokinetics. • Prior experience in CNS drug discovery is essential, including a successful track record of delivering brain-penetrant candidate compounds for brain disorders. • Track record of successfully managing projects remotely through multiple and CRO partners. • Clear record of accomplishments as exemplified through patents and/or publications.

🏖️ Benefits

• annual bonus opportunity • medical, dental, vision, life and AD&D • short term and long term disability • 401(K) plan with match • stock options • flexible non-accrual paid time off • parental leave