Principal Scientist, ADME/PK

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Shasqi

WebsiteLinkedInAll Job Openings

11 - 50 employees

Founded 2015

🧬 Biotechnology

💊 Pharmaceuticals

💰 $1.9M Grant on 2022-01

Biotechnology • Pharmaceuticals

Shasqi is a clinical-stage biotech company developing a pre-targeting tumor therapy platform called CAPAC (Click Activated Protodrugs Against Cancer) that uses in‑vivo click chemistry to capture and activate therapeutic payloads at tumors. Their modular approach separates a tumor-binding clickable molecule from an inert clickable payload (radioisotope or chemotherapy protodrug) which becomes activated or locked at the tumor after a bioorthogonal click reaction, aiming to increase tumor drug concentration and reduce systemic toxicity. Shasqi reports clinical validation of the platform and is advancing pipeline assets and collaborations to bring pre‑targeted cancer therapies to patients.

📋 Description

• Define and execute ADME/PK strategies for pre-targeted therapeutics that consist of biologics and small molecules. • Lead PK/PD and biodistribution strategy to support platform validation and pipeline programs. • Partner cross-functionally with chemistry, protein engineering, bioanalytical, and pharmacology/toxicology teams to optimize delivery efficiency and exposure. • Serve as the subject matter expert on PK for pre-targeting systems and click chemistry-enabled therapeutics. • Design, analyze, and interpret PK, biodistribution, and mass balance studies across components of the technology to guide therapeutic design, validation, and development. • Build and apply PK/PD and mechanistic models to predict human dosing and scheduling. • Present data and strategy to leadership, investors, and external collaborators.

🎯 Requirements

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Bioengineering, or related field. • 4+ years of industry experience in ADME/PK (biotech/pharma), including ADME/PK leadership on therapeutic programs. • Deep expertise in PK of biologics and/or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics). • Strong experience designing and interpreting in vivo PK and biodistribution studies. • Demonstrated experience with QSP and PK/PD modeling. • Experience with modeling tools (e.g., Phoenix WinNonlin, NONMEM, Monolix, MATLAB, or similar).

🏖️ Benefits

• Competitive base salary as part of a broader total rewards package. • Equity: Included as port of total compensations. • Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability. • Flexible PTO and a WFH stipend to support remote work. • Ongoing growth opportunities, professional development, and mentorship.