Principal Enterprise AI and Transformation Architect

🔥 0 minutes ago

🇺🇸 United States – Remote

💵 $115k - $130k / year

⏰ Full Time

🔴 Lead

🤖 Artificial Intelligence

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Simulations Plus, Inc.

WebsiteLinkedInAll Job Openings

201 - 500 employees

Founded 1996

💊 Pharmaceuticals

🧬 Biotechnology

☁️ SaaS

💰 Grant - Simulations Plus on 2024-11

Pharmaceuticals • Biotechnology • SaaS

Simulations Plus, Inc. is a science-driven software and consulting company that provides mechanistic modeling, AI-enabled workflows, and expert services to support model‑informed drug development (MIDD) across discovery, development, clinical operations, and commercialization. Its product suite includes GastroPlus (PBPK/PBBM), MonolixSuite (pharmacometrics), ADMET Predictor (ML for ADMET), DILIsym (quantitative systems toxicology), Thales (QSP), and Pro‑ficiency (learning/simulation), and the company offers consulting, training, regulatory strategy support, and bundled solution packages. Simulations Plus emphasizes mechanistic and AI-enabled tools for ADMET prediction, PBPK, pharmacometrics, QSP/QST and serves pharmaceutical and biotech clients (noting ~30+ years in business, ~280+ clients and use by 19 of the top 20 pharma companies).

📋 Description

• Discover transformation opportunities and translate future-state process designs into technical solution architectures, prototypes, and implementation plans • Lead technical discovery and feasibility assessments for complex transformation initiatives • Translate business and process requirements into technical designs, working prototypes, implementation plans, and production solutions • Own technical delivery through architecture, prototyping, build, testing, deployment, and stabilization • Design, configure, build, test, and deploy enterprise AI workflows, copilots, intelligent agents, and automation solutions • Engineer agent instructions, prompts, tools, knowledge connections, APIs, guardrails, escalation paths, evaluation, and monitoring mechanisms • Build reusable workflows, prompt libraries, agent patterns, connectors, templates, and components • Troubleshoot, tune, optimize, and support deployed solutions • Design and implement enterprise-system configurations, workflows, business rules, and data structures • Design and build API-based and platform-based integrations across ERP, CRM, financial, project management, collaboration, operational, data, automation, and AI systems • Resolve complex technical problems involving authentication, APIs, data flows, integration logic, exception handling, automation, and AI • Align solutions with enterprise architecture, configuration standards, integration patterns, security requirements, and change controls • Transition ongoing ownership of configurations and integrations to appropriate system owners • Design end-to-end solutions spanning business processes, enterprise systems, data, integrations, automation platforms, and AI services • Develop solution architecture and platform recommendations balancing scalability, security, compliance, maintainability, user experience, and total cost of ownership • Create reference patterns, design artifacts, and implementation standards • Serve as technical lead and escalation point while remaining directly involved in prototyping and implementation • Build proofs of concept and working prototypes; convert successful prototypes into production-ready solutions • Evaluate emerging AI, automation, integration, and enterprise platform capabilities through practical experimentation • Recommend whether to build, buy, configure, integrate, or retire capabilities • Implement responsible AI, security, privacy, data-use, human-oversight, documentation, testing, release, and support requirements • Build evaluation and quality-assurance approaches for AI outputs, agent behavior, workflow reliability, and exception handling • Partner with Legal, Information Security, IT, Quality, and business stakeholders on regulatory and enterprise requirements • Create standards and reusable controls supporting governance and compliance • Prepare users, process owners, and support teams for new ways of working • Create technical documentation and knowledge-transfer plans • Scale successful solutions across functions using reusable patterns, components, integrations, and playbooks • Communicate solution options, tradeoffs, progress, risks, and outcomes to executive, business, and technical audiences • Act as thought partner to the Executive Director while owning priority transformation and AI work • Mentor managers, architects, analysts, and solution teams through pairing, design sessions, reviews, and hands-on problem solving • Influence across functions and align business teams, IT, vendors, and implementation partners • Perform other duties as assigned

🎯 Requirements

• 8+ years of experience spanning business transformation, enterprise systems, solution architecture, intelligent automation, systems integration, AI enablement, or consulting roles • Demonstrated hands-on experience designing, configuring, building, integrating, testing, deploying, and supporting enterprise solutions • Hands-on experience building AI-enabled workflows, copilots, intelligent agents, retrieval-augmented solutions, or generative AI applications • Hands-on experience configuring and integrating enterprise business systems and low-code platforms, such as ERP, CRM, Microsoft Power Platform, Copilot Studio, Dynamics, Salesforce, Freshworks, or comparable technologies • Hands-on experience designing, building, and troubleshooting API-based integrations, including REST APIs, authentication, data flows, integration patterns, connectors, and event-driven processes • Ability to translate ambiguous business challenges into technical solutions, working prototypes, and production implementations • Experience designing human + AI workflows, prompts, tools, guardrails, evaluation methods, exception handling, and operational support models • Ability to move fluidly between executive strategy, workshop facilitation, architecture, configuration, development, testing, deployment, and support • Portfolio or examples demonstrating personally delivered AI, automation, integration, or enterprise system solutions strongly preferred • Excellent executive communication, facilitation, documentation, presentation, and stakeholder management skills • Experience delivering cross-functional initiatives in regulated or enterprise environments • Experience in life sciences, healthcare, GxP, SOX, or similarly regulated environments preferred • Enterprise architecture, cloud, Microsoft, AI, automation, Lean, Six Sigma, or related certifications preferred • Occasional travel required for meetings, trainings, and conferences • Bachelor's degree in information systems, computer science, engineering, operations, pharmaceutical sciences, or related field • Master's degree in information systems, computer science, engineering, operations, pharmaceutical sciences, or related field preferred • Advanced enterprise architecture, cloud, automation, or AI certifications a plus

🏖️ Benefits

• Fully remote work • Flexible schedules • Generous vacation policy • Affordable health coverage • Annual bonus