Senior Director, Real World Evidence – Center of Excellence Lead

🔥 6 minutes ago

🏄 California – Remote

🏄 California – Remote

💵 $280k - $308k / year

⏰ Full Time

🟠 Senior

👔 Director

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Crinetics Pharmaceuticals

WebsiteLinkedInAll Job Openings

201 - 500 employees

Founded 2015

🧬 Biotechnology

💊 Pharmaceuticals

⚕️ Healthcare Insurance

Biotechnology • Pharmaceuticals • Healthcare Insurance

Crinetics Pharmaceuticals is a biotechnology company that develops innovative therapies for endocrine diseases. The company is focused on addressing unmet medical needs by creating treatments for conditions such as acromegaly, carcinoid syndrome, ACTH-dependent Cushing’s syndrome, congenital adrenal hyperplasia, and other endocrine disorders. Crinetics is committed to improving the quality of life for patients through cutting-edge science and robust clinical trials. Their pipeline includes promising candidates like paltusotine, which has been accepted by the U. S. Food and Drug Administration for the treatment of adult patients with acromegaly. The company collaborates with healthcare practitioners and stakeholders to ensure that their therapies address real-life problems effectively and build value for investors by entering market niches with significant needs.

📋 Description

• Lead the delivery of the real-world evidence program across the portfolio, translating evidence priorities into rigorous, well-designed real-world studies. • Provide leadership, career management, coaching, and mentoring to a team of RWE Scientists; recruit and develop talent and align team capacity to portfolio demand. • Drive team objectives, prioritization, and resource allocation across competing therapeutic area needs. • Operate across long-range lifecycle planning and near-term execution horizons. • Design and oversee burden-of-illness, natural history, patient journey, drug utilization, external control arm, comparative effectiveness, and HTA-supportive real-world studies. • Contribute to the design and operationalization of Crinetics-sponsored registries and lead registry-related analytics and evidence generation. • Lead analyses using large healthcare databases and primary real-world data collection methods. • Establish methodological standards, protocol templates, statistical analysis frameworks, and quality benchmarks. • Conduct and supervise feasibility assessments, database selection, and study-design innovation. • Partner with IT and Commercial to shape enterprise real-world data sourcing and analytics infrastructure. • Lead the RWE module of CrinRADAR, supporting scalable and automated evidence generation. • Establish data governance, contracting, and vendor management standards for real-world data assets. • Partner with HEOR Therapeutic Area Leads to translate franchise-level evidence questions into executable plans. • Contribute evidence to integrated evidence plans, value dossiers, and HTA submissions. • Collaborate cross-functionally with Clinical Development, Biometrics, Regulatory, and Patient Advocacy. • Build and steward external partnerships with academic investigators, data providers, and analytics vendors. • Lead publication strategy and external scientific communication for the real-world evidence program. • Represent Crinetics at scientific congresses and remain current with evolving real-world evidence methodologies and guidance. • Ensure compliance with corporate policies and applicable healthcare laws and regulations.

🎯 Requirements

• Advanced degree in epidemiology, biostatistics, health services research, health economics, or related discipline (PhD, MD, PharmD, MPH, MSc) • Minimum of 13 years of relevant pharmaceutical, biotechnology, or HEOR consulting experience • Minimum of 10 years supervisory years of experience • Demonstrated expertise in designing and executing observational studies using large real-world datasets across the product lifecycle • Experience leading center-of-excellence or function-level real-world evidence programs across multiple assets • Experience building and managing external real-world data vendor partnerships • Working knowledge of regulatory and HTA evidence requirements • Experience delivering real-world evidence into value dossiers and HTA submissions • Strong analytical, quantitative, and methodological expertise • Excellent communication and interpersonal skills with the ability to influence senior leaders • Ability to lead, collaborate, and influence cross-functional teams • Flexible, adaptable, and effective in ambiguous environments.

🏖️ Benefits

• discretionary annual target bonus • stock options • ESPP • 401k match • health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance • 20 days of PTO • 10 paid holidays • winter company shutdown