Director, Preclinical Program Leadership

🕒 May 22

🌽 Illinois – Remote

🌽 Illinois – Remote

💵 $175k - $250k / year

⏰ Full Time

🟠 Senior

📋 Program Manager

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Evozyne

WebsiteLinkedInAll Job Openings

51 - 200 employees

Founded 2020

🧬 Biotechnology

💊 Pharmaceuticals

🤖 Artificial Intelligence

💰 $81M Series B - Evozyne on 2023-09

Biotechnology • Pharmaceuticals • Artificial Intelligence

Evozyne is an AI-native biotechnology company that designs de novo therapeutic proteins to treat immune‑mediated diseases. Its EvoGen generative AI engine designs protein sequences optimized for potency, stability, specificity, and low immunogenicity, and its EvoLab high-throughput experimental facility builds and tests thousands of candidates each design cycle to generate proprietary data. Evozyne advances engineered proteins—including IgG proteases, next‑generation cytokines, and respiratory disease candidates—toward clinical evaluation to address patients who do not respond to existing biologics or small molecules.

📋 Description

• Own program execution and operations from candidate nomination through IND clearance and Phase 1 enablement across multiple assets in parallel • Drive the critical path, including timelines, budgets, dependencies, and decision points • Build and maintain integrated development plans spanning workstreams across multiple functional areas • Translate program progress into clear, actionable updates and recommendations for leadership • Own external partnerships with CROs and CDMOs, including vendor selection, scope definition, and ongoing performance management • Negotiate scope, cost, timelines, and deliverables, and hold partners accountable to outcomes • Coordinate across multiple vendors simultaneously, managing handoffs, data flow, and interdependencies • Partner with internal technical experts to design studies and translate program needs into effective external workstreams • Oversee development of study protocols, incorporating cross-functional input and aligning stakeholders • Build the internal playbooks, processes, and operating structures needed to scale program execution across the pipeline

🎯 Requirements

• Direct operational ownership of multiple IND programs in biologics, with at least one specifically in functional protein therapeutics • Advanced degree in biochemical, pharmacology, toxicology or related field such as biology and life sciences • 8+ years (Ph.D.) to 12+ years (Master’s) of relevant industry experience • Demonstrated success leading programs through CROs and CDMOs, including global vendors. • Deep understanding of the drug development process from discovery through IND filing • Strong familiarity with GxP, ICH guidelines, and FDA preclinical requirements • Proven ability to align and influence stakeholders across functions and organizations

🏖️ Benefits

• Opportunity to drive multiple programs from candidate nomination through IND and into the clinic in a highly integrated, fast-moving environment • Ability to work at the intersection of AI, biology, and experimental science on problems where the path forward is not always clear • Significant ownership and influence on how preclinical programs are executed, prioritized, and scaled as the pipeline grows • Exposure to both strategic decisions and hands-on execution in a lean team where your work directly impacts program outcomes