Principal Scientist, Immunology

🔥 9 minutes ago

🏄 California, Washington – Remote

🏄 California – Remote ☕ Washington – Remote

💵 $175k - $190k / year

⏰ Full Time

🔴 Lead

🧬 Research Scientist

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Jade Biosciences

WebsiteLinkedInAll Job Openings

11 - 50 employees

Founded 2024

🧬 Biotechnology

💊 Pharmaceuticals

Biotechnology • Pharmaceuticals

Jade Biosciences is a clinical-stage biotechnology company developing potentially best-in-class therapies aimed at transforming the standard of care for autoimmune diseases. Its lead candidate, JADE101, is an antibody designed to inhibit the cytokine APRIL (A PRoliferation-Inducing Ligand) and is being developed for the treatment of immunoglobulin A nephropathy (IgAN). The company builds its pipeline from discovery-stage assets licensed from Paragon Therapeutics and is focused on advancing clinical programs to deliver new treatments for patients with autoimmune conditions.

📋 Description

• Lead immunology-driven research strategy across pipeline programs to support scientific narrative and indication assessment, integrating literature, experimental data, and translational insights • Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs • Partner closely with Translational Medicine, Clinical Pharmacology, and Nonclinical teams to ensure alignment of preclinical findings with clinical strategy • Generate and interpret complex datasets (e.g., cellular immunology, cytokine profiling, pathway analysis), ensuring rigorous and hypothesis-driven conclusions • Identify and validate new targets and pathways for pipeline expansion, leveraging deep understanding of disease biology, emerging science, and internal platform capabilities • Evaluate and prioritize new indication opportunities, integrating mechanistic rationale, competitive landscape, and translational feasibility • Support external collaborations and CRO activities, providing scientific direction and technical oversight to ensure high-quality data generation • Author and contribute to scientific documents, including study reports, regulatory sections (e.g., IND-enabling rationale), presentations, and publications • Present findings to internal governance teams and external scientific forums • Stay current with advances in immunology, inflammation, and translational science, applying new insights to strengthen program and pipeline strategy

🎯 Requirements

• PhD in Immunology or related field with 8–12+ years of relevant industry experience is required • Deep expertise in immunology and disease biology, particularly in autoimmune and inflammatory disease mechanisms • Strong understanding of drug development, including how preclinical and translational data inform clinical strategy • Experience with immunological assays and platforms (e.g., flow cytometry, ELISA/MSD, cytokine panels, cellular assays); familiarity with advanced platforms (e.g., single-cell, proteomics) is a plus • Experience working in cross-functional teams (e.g., Translational Medicine, Clinical, Nonclinical) • Strong written and verbal communication skills, with a track record of scientific publications and presentations • Ability to operate independently while contributing to a collaborative, fast-paced biotech environment.