Executive Director, Biomarkers

🕒 July 17

🔔 Pennsylvania – Remote

🔔 Pennsylvania – Remote

💵 $276k - $414k / year

⏰ Full Time

🔴 Lead

👔 Director

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Jazz Pharmaceuticals

WebsiteLinkedInAll Job Openings

1001 - 5000 employees

Founded 2003

🏥 Healthcare

🏭 Manufacturing

🧬 Biotechnology

Healthcare • Manufacturing • Biotechnology

Jazz Pharmaceuticals is a biopharmaceutical company dedicated to developing innovative medicines that address serious unmet medical needs. With a strong commitment to research and development, Jazz focuses on creating life-changing therapies, emphasizing the importance of collaboration, diversity, and employee engagement in its operations. The company prides itself on transforming patients' lives through its meaningful product offerings and a culture that fosters enthusiasm and flexibility.

📋 Description

• Lead enterprise-wide biomarker strategy across the portfolio with an emphasis on oncology • Own the end-to-end biomarker strategy for oncology programs through design, execution, analyzing, and reporting correlative biomarker studies for clinical trials (Phase 0–3) and nonclinical work • Lead Companion Diagnostic (CDx) strategy; define intended use, select/manage diagnostic partners/CROs, oversee analytical/clinical validation, and align on regulatory pathways • Embed patient selection/enrichment strategies and biomarker endpoints into protocols and SAPs in partnership with Clinical Development, Biostatistics, and Regulatory • Build and lead a high‑performing biomarker team; manage budgets, timelines, vendors, and academic collaborations • Communicate strategy, risks, and recommendations to R&D leadership; represent the company with partners, KOLs, and scientific consortia

🎯 Requirements

• Oncology experience REQUIRED with deep knowledge of tumor biology, heterogeneity, clinical development, and regulatory considerations • Non‑oncology biomarker experience PREFERRED (e.g., neuroscience) to cross‑pollinate best practices • Proven track record delivering biomarker strategies and CDx programs, including analytical/clinical validation and regulatory submissions • Fluency in multi‑omic data (genomics, transcriptomics, proteomics, metabolomics) and molecular assay platforms (IHC/ISH, NGS, PCR, flow cytometry, mass spec, ctDNA) • Experience designing correlative science for both clinical trials and nonclinical studies; ability to translate mechanism of action into measurable pharmacodynamic and patient‑selection hypotheses • Strong leadership in matrixed environments; ability to influence without authority and manage external partners/CROs • Excellent oral and written communication; ability to author and review technical and regulatory documents • Doctoral degree (PhD, MD, or MD/PhD) in molecular biology, genomics, bioinformatics, biomedical engineering, or related field, with significant experience in a drug development setting and significant oncology biomarker leadership • Preferred: ASCP/MGP or clinical laboratory certifications.

🏖️ Benefits

• medical, dental and vision insurance • 401k retirement savings plan • flexible paid vacation • discretionary annual cash bonus or incentive compensation • discretionary equity grants