Lead Bioinformatics Scientist – Oncology

🔥 10 minutes ago

🇺🇸 United States – Remote

💵 $130.9k - $163.6k / year

⏰ Full Time

🟠 Senior

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Natera

WebsiteLinkedInAll Job Openings

1001 - 5000 employees

Founded 2004

🏥 Healthcare

🧬 Biotechnology

⚕️ Healthcare Insurance

Healthcare • Biotechnology • Healthcare Insurance

Natera is a global leader in cell-free DNA testing technology, specializing in non-invasive genetic testing and diagnostics. The company's innovative solutions focus on areas such as prenatal screening, cancer detection, and organ transplant monitoring. By using advanced bioinformatics and DNA analysis, Natera provides healthcare professionals and patients with critical information to make more informed medical decisions.

📋 Description

• Lead the analytical validation strategy for an NGS-based assay • Design, analyze, and troubleshoot feasibility and performance evaluation studies, including PPA and LoD • Drive real-world evidence studies demonstrating clinical utility for therapy selection and patient management • Select cohorts and analyze plasma mutation calls • Build rapid prototypes and pipelines integrating data from multiple Natera products • Develop algorithms and tools for new products and contribute to the production bioinformatics pipeline • Act as an internal technical consultant on bioinformatics methodology • Collaborate with assay development, engineering, biostatistics, clinical, commercial, regulatory, and lab operations teams • Contribute to regulatory submissions, clinical study reports, and scientific publications

🎯 Requirements

• Master’s degree in bioinformatics or a related field with 10 years of post-graduate experience, or PhD with 5 years of post-graduate experience (preferred) • Expert knowledge of bioinformatics tools for NGS, including sequencing QC and secondary analysis such as variant calling • Experience with WES/WGS/targeted sequencing of tissue and cfDNA • Experience with somatic variant calling, including SNVs, indels, CNVs, and fusions • Working knowledge of statistical methods for assay performance evaluation • Strong programming and scripting skills in Python, R, and shell • Fluency in exploratory data analysis and visualization of complex datasets • Deep understanding of NGS workflows from sample extraction to sequencing • Ability to communicate technical concepts clearly with wet lab groups and cross-functional partners • Ability to work independently while managing multiple objectives and timelines • Experience supporting regulated or clinical-grade assay development, including CLIA/CAP and FDA submissions (preferred) • Familiarity with clinical genomics and oncology variant interpretation (preferred) • Experience with translational or real-world data analysis integrating clinical and genomic data (preferred)

🏖️ Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents • Free testing for employees and immediate families • Fertility care benefits • Pregnancy and baby bonding leave • 401(k) benefits • Commuter benefits • Employee referral program

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