Principal AI Engineer

🔥 1 minute ago

🇺🇸 United States – Remote

⏰ Full Time

🔴 Lead

🤖 AI Engineer

🦅 H1B Visa Sponsor

This company has sponsored H1B visas in the past.

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Natera

WebsiteLinkedInAll Job Openings

1001 - 5000 employees

Founded 2004

🏥 Healthcare

🧬 Biotechnology

⚕️ Healthcare Insurance

Healthcare • Biotechnology • Healthcare Insurance

Natera is a global leader in cell-free DNA testing technology, specializing in non-invasive genetic testing and diagnostics. The company's innovative solutions focus on areas such as prenatal screening, cancer detection, and organ transplant monitoring. By using advanced bioinformatics and DNA analysis, Natera provides healthcare professionals and patients with critical information to make more informed medical decisions.

📋 Description

• Own platform architecture and hands-on delivery for the Vector Store GenAI Platform, including search and retrieval, document processing and chunking, ingestion pipelines, and APIs serving downstream AI workflows • Set technical direction for hybrid search and retrieval quality • Evaluate embedding models and retrieval approaches through implementations, POCs, and benchmarks • Advance document parsing and chunking for accurate, structured, and faceted retrieval • Build stable, reproducible retrieval for agent and re-extraction workloads, including durable content identifiers, context assembly, versioned indices, and quality or confidence signals • Strengthen document classification and ingestion visibility across historical and ongoing data flows • Improve retrieval quality through deduplication, clinical concept normalization, and promising retrieval methods • Integrate LLM capabilities into production systems with attention to performance, scalability, cost, observability, and safe operation in a regulated environment • Partner with clinical AI, engineering, product, and SME stakeholders to prioritize workstreams, define success metrics, and sequence roadmap investments • Provide principal-level technical leadership through architecture decisions, design reviews, documentation, mentoring influence, and pragmatic tradeoffs

🎯 Requirements

• Bachelor’s or Master’s degree in Computer Science, Engineering, or a related technical field • 10+ years of software engineering experience, including substantial ownership of production systems at scale • 5+ years building and shipping AI/ML-powered applications in production • Deep hands-on experience in retrieval-augmented systems, vector search, and document-centric AI pipelines, including indexing, retrieval quality, evaluation, and integration with downstream LLM or agent systems • Demonstrated track record as a principal or equivalent individual contributor • Strong hands-on expertise in Python and modern software engineering practices, including testing, code review, workflow orchestration, and agile delivery in large existing codebases • Experience designing and operating AI systems in cloud environments; AWS strongly preferred • Experience with CI/CD, observability, and production support • Ability to work independently as an architecture-plus-build individual contributor and influence without direct authority • Strong communication across technical and non-technical audiences • Experience with clinical or structured healthcare documents and document-centric search or RAG systems is strongly preferred • Experience in healthcare, life sciences, or other regulated industries is strongly preferred • Experience designing retrieval interfaces used by agents or multi-step LLM workflows is a plus

🏖️ Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents • Free testing for Natera employees and their immediate families • Fertility care benefits • Pregnancy and baby bonding leave • 401k benefits • Commuter benefits • Employee referral program