Neurocrine Biosciences
1001 - 5000 employees
Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science.
Senior Scientist, Computational Chemistry
🕒 May 26
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Neurocrine Biosciences
1001 - 5000 employees
Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science.
📋 Description
• Responsible for execution of computational driven methodologies to help design optimized compounds in drug discovery programs • Projects could range from early lead identification to late-stage optimization phase • Member of multi-disciplinary drug discovery teams of medicinal chemists, DMPK, structural biologists, and pharmacologists • Expertise with structure-based design methods to support drug discovery projects in the industry • Contribute to the Computational Chemistry group’s efforts in implementing computational chemistry and/or cheminformatics methods • Generate productive hypotheses from Protein-ligand docking for project teams • Develop advanced Machine Learning/AI in-silico models for numerous DMPK/in-vitro Biology endpoints • Facilitate medicinal chemists in designing new compounds with desirable properties • Identify and help develop/refine new computational methods to augment Neurocrine's Computational Chemistry platform for Drug Discovery • Engage stakeholders from multiple research functions to deliver and/or exchange key results.
🎯 Requirements
• BS/BA degree in Chemistry and 5+ years of relevant experience • Familiarity utilizing Machine Learning/AI based predictive modeling, Cheminformatics, Protein-Ligand modeling • MS/MA degree in Chemistry and 3+ years of similar experience noted above OR 3+ years of post-Ph.D experience preferred • Strong knowledge of scientific discipline • Good knowledge of scientific principles, methods and techniques • Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools • Strong computer skills • Good problem-solving, analytical thinking skills • Detail oriented • Ability to meet deadlines • Excellent communication skills with the ability to collaborate with cross-functional scientists.
🏖️ Benefits
• Health insurance • 401(k) • Paid time off • Flexible work arrangements
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