Senior Principal Scientist – Antibody-siRNA Bioanalytical, Biodistribution Strategy Lead

🕒 March 12

🇺🇸 United States – Remote

💵 $184k - $204.8k / year

⏰ Full Time

🟠 Senior

🧬 Research Scientist

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Amgen

WebsiteLinkedInAll Job Openings

10,000+ employees

Founded 1980

🧬 Biotechnology

💊 Pharmaceuticals

🔬 Science

💰 $28.5G Post-IPO Debt on 2022-12

Biotechnology • Pharmaceuticals • Science

Amgen is a global leader in biotechnology, focusing on the development and commercialization of innovative medicines made from living cells. The company aims to treat serious illnesses, often targeting diseases with limited therapeutic options. Amgen emphasizes scientific innovation and is committed to ethical research, patient safety, and environmental sustainability. It actively engages in clinical trials and is known for its contributions to the fields of cancer treatment and obesity management among others.

📋 Description

• Lead the strategy and execution of innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples (in vitro and in vivo) • Lead strategy to establish innovative in vitro ADME assays for antibody-siRNA conjugates • Design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics of antibody-siRNA conjugates • PKDM-BA project team representative for antibody-siRNA conjugates and other siRNA modalities • Lead and execute on preparation of the pharmacokinetic written summary for regulatory applications • Mentor and cross-train PKDM-BA scientific colleagues • Build and foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept

🎯 Requirements

• Doctorate degree [and relevant post-doc where applicable] in pharmacology, biochemistry or a related-scientific discipline and 3 years of industry experience • Or Master’s degree in pharmacology, biochemistry or a related-scientific discipline and 6 years of industry experience • Or Bachelor’s degree in pharmacology, biochemistry or a related-scientific discipline and 8 years of industry experience • Extensive knowledge of antibody-siRNA conjugate ADME and pharmacokinetics • Experience with respect to other siRNA modalities, antibody-drug conjugates, peptide conjugates, biologics and/or small molecules • Experience investigating biodistribution and metabolism of siRNA conjugated to a tissue-targeting ligand • Expertise in antibody-siRNA bioanalytical approaches and considerations • Extensive experience with ligand binding assays (specifically immunoassay and hybridization assays) and LC/MS bioanalytical platforms • Experience with respect to RT-qPCR and/or RT-ddPCR • Exceptional written and verbal communication skills • Experience with regulatory filings for antibody-siRNA conjugates and/or other targeted delivery siRNA therapeutics.

🏖️ Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions • group medical, dental and vision coverage • life and disability insurance • flexible spending accounts • A discretionary annual bonus program • Stock-based long-term incentives • Award-winning time-off plans • Flexible work models where possible.