Manager, Genetic Quality Assurance, Product Quality – Variant Interpretation, Genomics

🕒 April 9

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Genomenon, Inc

WebsiteLinkedInAll Job Openings

51 - 200 employees

Founded 2016

🧬 Biotechnology

⚕️ Healthcare Insurance

💊 Pharmaceuticals

💰 $20M Series B on 2022-03

Biotechnology • Healthcare Insurance • Pharmaceuticals

Genomenon, Inc. is a company offering innovative solutions in genomic data interpretation for clinical diagnostics and precision therapeutics. Their Mastermind Genomic Intelligence Platform uses AI to analyze and interpret vast datasets, offering insights into over 26 million variants and curated germline variant content. Genomenon provides software, data, and expert consulting services to support genomic research, drug development, and the commercialization of genomic therapies. They focus on accelerating NGS variant interpretation to enhance diagnostic yield and inform drug programs by connecting genomic variants to therapies and clinical trials.

📋 Description

• Serve as the final scientific authority for complex or ambiguous variant interpretation cases, including conflicting clinical and functional evidence • Apply deep expertise in ACMG/AMP guidelines to ensure accurate and defensible classifications • Leverage clinical experience to contextualize variant interpretations and ensure clinical relevance and applicability • Guide evaluation of functional studies and literature to support high-confidence interpretation decisions • Support high-impact client deliverables, including clinical and pharmaceutical use cases • Own QA/QC standards across all variant interpretation workflows • Ensure consistent application of internal frameworks, nomenclature standards (HGVS), and interpretation criteria • Oversee external data quality, including ClinVar submissions and discrepancy resolution • Manage, mentor, and develop a team of QA scientists and curators • Provide coaching on interpretation, evidence evaluation, and best practices • Set clear performance expectations and maintain accountability for quality standards • Design, implement, and continuously improve SOPs, QA processes, and workflows • Identify systemic quality issues and lead solutions that scale across teams and projects • Balance standardization with flexibility to meet diverse client and product needs • Partner with product, engineering, and leadership to improve tools, workflows, and data quality • Contribute to broader data and product strategy through scientific expertise

🎯 Requirements

• 5+ years of hands-on variant interpretation experience in a clinical or equivalent setting • Advanced degree (PhD, MS in Genetics/Genomics) or Genetic Counselor (CGC) • Deep expertise applying ACMG/AMP guidelines in complex scenarios • Strong experience evaluating clinical and functional evidence from scientific literature • Proficiency in HGVS nomenclature, including normalization and variant disambiguation • Demonstrated ability to make independent, high-confidence scientific decisions.

🏖️ Benefits

• Health insurance • 401(k) matching • Flexible work hours • Paid time off • Remote work options