Senior Scientist II, Recombinant Peptide Process Development

🔥 0 minutes ago

🏄 California – Remote

🏄 California – Remote

💵 $109.5k - $208.5k / year

⏰ Full Time

🟠 Senior

🦅 H1B Visa Sponsor

This company has sponsored H1B visas in the past.

👻 Ghost score 0%

What it means: the chance that no one is really hiring for this job.How to read it: 60% or higher means we think this is a ghost. Lower scores are less of a worry.How we score it: age, reposts, open roles vs team size, how fast jobs close, and whether pay is listed.Fine print: an estimate from public data, not a judgment of the company. Real jobs can score high, so treat it as a hint, not a fact.

Apply Now

Find Similar Remote Jobs

AbbVie

WebsiteLinkedInAll Job Openings

10,000+ employees

Founded 2013

🏥 Healthcare

💼 Consulting

🏭 Manufacturing

Healthcare • Consulting • Manufacturing

AbbVie is a global pharmaceutical company that discovers and delivers innovative medicines and solutions to enhance lives. With a focus on addressing the world's toughest health challenges, AbbVie operates in over 175 countries, providing a wide range of products across areas like immunology, oncology, neuroscience, and aesthetics. Committed to scientific innovation, AbbVie invests heavily in research and development, aiming to produce first-in-class medicines. The company also emphasizes workplace diversity, sustainability, and patient support initiatives, ensuring positive impact for both its patients and the broader community.

📋 Description

• Lead recombinant peptide process-development activities, including expression strategy, host and clone screening, process optimization, and scale-up • Design and evaluate expression constructs and microbial hosts, including Escherichia coli and yeast • Develop and assess fusion-tag and carrier-protein strategies, including His-tag, GST, SUMO, and inclusion-body expression • Design and conduct clone-screening studies using microscale cultivation, parallel bioreactors, and other scale-down or high-throughput approaches • Develop and optimize peptide recovery processes, including cell harvest and lysis, inclusion-body isolation and processing, and chemical or enzymatic cleavage of fusion partners • Troubleshoot aggregation, low solubility, degradation, incomplete cleavage, and co-eluting impurities • Interpret HPLC, UPLC, and LC-MS data to assess peptide identity, mass accuracy, purity, and process-related impurities • Evaluate emerging technologies and process approaches, including genetic code expansion when relevant • Apply AI/ML approaches to analyze peptide sequence, structure, and experimental data • Communicate scientific plans, progress, challenges, conclusions, and recommendations to project teams and stakeholders • Mentor junior scientists and provide technical direction in recombinant peptide bioprocessing • Contribute to scientific publications and conference presentations • Manage priorities and timelines while following corporate standards for safety, quality, and compliance

🎯 Requirements

• PhD with typically 4+ years of relevant experience, master’s degree or equivalent education with 10+ years of relevant experience, or bachelor’s degree or equivalent education with typically 12+ years of relevant experience • Thorough theoretical and practical understanding of relevant scientific disciplines • Hands-on experience in microbial physiology and recombinant expression systems, particularly E. coli and/or yeast • Ability to independently design, execute, and interpret critical experiments • Experience developing or optimizing expression processes for peptides, small proteins, or other products susceptible to degradation or instability • Experience with strain or clone screening, fermentation, and process optimization • Familiarity with bioreactors and scale-down or parallel cultivation approaches • Experience with preparative chromatography and peptide or protein purification • Experience with peptide recovery and fusion-partner cleavage strategies • Strong experimental design, data interpretation, troubleshooting, scientific writing, and oral communication skills • Ability to manage multiple priorities and timelines and work effectively in a matrixed, cross-functional environment

🏖️ Benefits

• Paid time off, including vacation, holidays, and sick leave • Medical, dental, and vision insurance • 401(k) • Eligibility to participate in long-term incentive programs

📊 Check your resume score for this job

Improve your chances of getting an interview by checking your resume score before you apply.

Upload Resume