Director – Translational Medicine

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🔥 0 minutes ago

🇺🇸 United States – Remote

💵 $235k - $310k / year

⏰ Full Time

🟠 Senior

🌎 Translator / Interpreter

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BBOT

WebsiteLinkedInAll Job Openings

51 - 200 employees

🏥 Healthcare

💼 Consulting

🧬 Biotechnology

Healthcare • Consulting • Biotechnology

BBOT is a biotechnology company developing targeted therapies for cancers driven by RAS signaling and PI3Kα. The company focuses on rational drug design to inhibit the active ON state of RAS and to selectively block RAS-driven PI3K activation, aiming at multiple KRAS mutants and novel approaches to maximize target inhibition. BBOT translates decades of RAS biology research into therapeutic candidates intended to improve outcomes for patients with RAS- and PI3Kα-driven tumors.

📋 Description

• Serve as the dedicated translational medicine lead for assigned BBOT programs • Define and own biomarker and translational strategies from preclinical studies through Phase 1/proof of concept • Provide scientific input into target validation, pharmacology, PK/PD, target engagement, mechanism of action, and patient selection strategies • Integrate preclinical findings with clinical development plans to inform dose selection, biomarker endpoints, and go/no-go criteria • Evaluate emerging study data, generate and test hypotheses, define resistance mechanisms, and adapt translational strategies • Represent translational perspectives on cross-functional program teams, clinical project teams, program governance, and portfolio reviews • Design, develop, and oversee hypothesis-driven biomarker plans, assay strategies, sample procedures, and statistical/analysis plans • Lead assay selection, qualification/validation strategy, and oversight through internal or external partners • Oversee clinical biomarker implementation for first-in-human and early-phase studies • Partner with clinical operations, CROs, academic labs, and diagnostic partners on sample logistics, data generation, documentation, and regulatory/quality readiness • Oversee junior biomarker operations employees as assigned • Ensure biomarker data meet quality standards for clinical study reports, regulatory filings, and scientific publications • Serve as subject matter expert in health authority interactions involving translational and biomarker content • Incorporate ctDNA/liquid biopsy, NGS, IHC/IF, and multi-omic technologies into translational approaches • Prepare and present translational updates, data reviews, protocol and investigator brochure sections, and recommendations • Contribute to resource planning, budgets, and timelines; manage vendor scopes and deliverables • Represent BBOT at scientific conferences, investigator meetings, and key opinion leader engagements • Contribute to publications and external scientific communications

🎯 Requirements

• Ph.D., M.D., or M.D./Ph.D. in oncology, molecular biology, pharmacology, or a related field • Director: minimum 7 years of experience in translational medicine, biomarker science, or oncology drug development in the pharmaceutical or biotechnology industry • Senior Director: minimum 10–12 years of experience in translational medicine, biomarker science, or oncology drug development, with a strong record of independent program ownership • Proven track record of designing and executing translational biomarker strategies in early-phase oncology trials • Solid understanding of RAS, PI3K, or related oncogenic signaling pathways • Hands-on experience with NGS, ctDNA/liquid biopsy, IHC/IF, flow cytometry, or equivalent biomarker platforms • Experience with CRO/vendor management for biomarker assay execution • Experience contributing to regulatory documents involving biomarker or translational content • Ability to communicate complex scientific concepts clearly to non-specialist audiences and senior stakeholders • Senior Director: ability to independently lead translational medicine strategy across multiple programs simultaneously • Senior Director: expertise in assay validation, clinical deployment, CDx pathway considerations, and regulatory interactions • Senior Director: advanced experience with genomic, molecular, and multi-omic profiling platforms • Senior Director: ability to integrate large, complex datasets into actionable translational insights • Senior Director: publications, conference presentations, and regulatory/KOL engagement • Prior experience in a lean, startup, or high-growth biotech environment is highly desirable