Director, Medicinal Chemistry

🔥 14 hours ago

🍂 Massachusetts – Remote

🍂 Massachusetts – Remote

💵 $150k - $210k / year

⏰ Full Time

🔴 Lead

👔 Director

👻 Ghost score 0%

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Centessa Pharmaceuticals

WebsiteLinkedInAll Job Openings

51 - 200 employees

Founded 2021

🏥 Healthcare

💼 Consulting

🧬 Biotechnology

Healthcare • Consulting • Biotechnology

Centessa Pharmaceuticals is a patient-focused biopharmaceutical company developing transformative medicines, with a pipeline centered on neuroscience. The company is advancing an Orexin Receptor 2 (OX2R) agonist program aimed at treating sleep-wake disorders and extending into neurological, neurodegenerative, and neuropsychiatric indications. Centessa employs proprietary technologies such as the LockBody® platform and follows an asset-centric approach to accelerate development for patients while engaging with investors and clinical programs like CRYSTAL-1.

📋 Description

• Lead the medicinal chemistry component of a multidisciplinary CNS GPCR drug discovery program • Guide a geographically distributed organization including internal chemistry staff, CRO-based synthetic chemistry teams, consultants, and partners • Lead and manage internal chemistry resources and outsourced chemistry teams • Set priorities, resolve synthetic challenges, and direct groups toward IND-ready candidate molecules • Serve as chemistry leader within the broader multidisciplinary project team • Build working relationships with colleagues, partners, consultants, and CROs • Design new molecules addressing the target product profile and establish intellectual property • Develop chemistry strategies supporting a robust intellectual property position • Analyze SAR from weekly pharmacology and ADME data to identify opportunities for improved molecules • Maintain awareness of competitor activities and medicinal chemistry developments • Maximize throughput of test compounds • Utilize structure-based drug design knowledge and compound-property computational predictive tools • Present data and articulate next steps at chemistry-focused and cross-functional meetings • Defend proposed designs using SAR and literature precedent • Communicate ideas clearly in writing and verbally with project teams and senior management

🎯 Requirements

• BS/MS Chemistry; PhD strongly preferred • 10+ years designing small molecules as a medicinal chemistry team leader within a biotech and/or pharmaceutical company • Expert command of synthetic chemistry and medicinal chemistry principles • Working knowledge of pharmacology, ADME, pharmaceutical sciences, IP protection, and candidate selection criteria • Experience working on CNS targets • Experience across all stages of discovery, from hit-to-lead and lead optimization through IND-ready candidates • Proven ability to lead and motivate remote and virtual teams toward aggressive timelines • Strong independent scientific judgment, interpersonal, and leadership skills • Experience managing outsourced chemistry teams • Adaptive problem-solving ability • Technical depth and a growth mindset • Curiosity and drive for self-identified innovation, especially involving artificial intelligence and digital tools

🏖️ Benefits

• Discretionary annual bonus • 401(k) plan • Company-sponsored medical insurance • Company-sponsored dental insurance • Company-sponsored vision insurance • Company-sponsored life insurance • Generous paid time off • Health and wellness program • Occasional travel associated with remote work

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