Vice President, Lifecycle Leader

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Kyverna Therapeutics

WebsiteLinkedInAll Job Openings

51 - 200 employees

Founded 2019

🧬 Biotechnology

💊 Pharmaceuticals

🔬 Science

💰 $85M Series B on 2022-01

Biotechnology • Pharmaceuticals • Science

Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases. The company is pioneering CAR T-cell therapies, leveraging the transformational power of T cells to potentially provide sustained, treatment-free remission for autoimmune conditions. Kyverna's lead CAR T-cell therapy candidate, KYV-101, is advancing through clinical trials targeting various autoimmune diseases, including multiple sclerosis, myasthenia gravis, systemic sclerosis, and lupus nephritis. Their pipeline features innovative chimeric antigen receptor (CAR) T-cell therapies in both autologous and allogeneic formats aimed at B cell-driven autoimmune diseases.

📋 Description

• Serve as the executive lifecycle lead for future indications and is accountable for the integrated asset strategy across clinical development, regulatory strategy, manufacturing readiness, and commercialization planning. • Define and maintain the integrated development plan and lifecycle strategy, aligned with the Target Product Profile and long-term commercial value drivers. • Drive strategic planning for key development milestones including Phase transitions, pivotal trial strategy, regulatory interactions, and launch readiness. • Ensure program execution is aligned with corporate strategy, timelines, regulatory requirements, and budget targets. • Lead and develop the Lifecycle Leaders organization, providing strategic oversight and mentorship to lifecycle leads across Kyverna’s development portfolio. • Establish best-in-class lifecycle governance, decision frameworks, and cross-program coordination processes. • Partner with the Executive Leadership Team to ensure portfolio prioritization and investment decisions align with corporate strategy and value creation. • Standardize lifecycle strategy development, program governance, and cross-functional planning across programs. • Serve as a primary strategic advisor to executive leadership on program strategy, portfolio risk, and lifecycle opportunities. • Lead preparation and presentation of program updates, strategic options, and decision packages to governance committees and the Board. • Ensure robust risk assessment, scenario planning, and mitigation strategies are in place across the program. • Define go/no-go decision points and guide governance discussions around program investment and strategic direction. • Represent Kyverna externally with key scientific, regulatory, and industry stakeholders. • Support strategic partnerships, collaborations, and licensing discussions where appropriate. • Engage with key opinion leaders and external experts to inform program strategy. • Ensure coordinated execution across all functional areas including: • Oversee the development and execution of key program deliverables including:

🎯 Requirements

• PhD, MD, PharmD, MBA or equivalent advanced degree preferred. • 15+ years of experience in biotechnology or pharmaceutical drug development, including significant leadership experience in clinical-stage programs. • Demonstrated success leading complex global development programs from early development through late-stage clinical trials and regulatory filings. • Experience serving as a program or lifecycle leader for a major therapeutic asset is required. • Experience in Neuroimmunology is strongly preferred. • Strong expertise in autoimmune disease, immunology, cell therapy, biologics, or related therapeutic areas strongly preferred. • Deep understanding of the end-to-end drug development value chain, including research, translational science, clinical development, regulatory, manufacturing, and commercialization. • Experience with global regulatory interactions and major submissions (IND, BLA, NDA). • Demonstrated leadership in cross-functional matrix organizations and enterprise governance structures. • Ability to interpret complex clinical and scientific data and translate insights into strategic decisions. • Experience leading cross-functional teams in high-growth biotechnology environments. • Strategic, enterprise-level thinker capable of driving portfolio-level impact. • Strong executive presence and ability to influence senior leadership and Board stakeholders. • Proven ability to lead high-performing cross-functional teams in complex, fast-moving environments. • Strong judgment and decision-making skills in the face of uncertainty and evolving scientific data. • Excellent communication and stakeholder management skills.

🏖️ Benefits

• This position is also eligible for bonus, benefits, and participation in Company’s stock plan.