Manager of Bioinformatics – Women's Health, Organ Health

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🇺🇸 United States – Remote

💵 $140k - $175k / year

⏰ Full Time

🟡 Mid-level

🟠 Senior

👔 Manager

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Natera

WebsiteLinkedInAll Job Openings

1001 - 5000 employees

Founded 2004

🏥 Healthcare

🧬 Biotechnology

⚕️ Healthcare Insurance

Healthcare • Biotechnology • Healthcare Insurance

Natera is a global leader in cell-free DNA testing technology, specializing in non-invasive genetic testing and diagnostics. The company's innovative solutions focus on areas such as prenatal screening, cancer detection, and organ transplant monitoring. By using advanced bioinformatics and DNA analysis, Natera provides healthcare professionals and patients with critical information to make more informed medical decisions.

📋 Description

• Lead production support for bioinformatics and data science algorithms behind Women's Health and Organ Health products • Lead a team of Data and Bioinformatics Scientists accountable for algorithm behavior on real samples • Own the interface between the Data and Bioinformatics Scientists and the production organization • Resolve inconclusive reports by assessing technical constraints and data quality issues • Determine upstream process changes to reduce inconclusive cases • Maintain a catalogue of known patterns for matching new cases to settled cases • Use AI to assemble and help interpret evidence during triage • Coordinate with Production Engineering, Product, the laboratory, and R&D to align changes in direction and scope • Define service commitments for turnaround and coverage • Build the processes and staffing needed to meet service commitments • Own production support and ensure answers are correct and timely • Lead cross-system investigations and identify ownership of fixes • Convert one-off investigations into durable rules and design changes • Own process validation for pipeline and algorithm changes • Define evidence requirements before changes enter sample-running workflows • Lead, hire, and develop Data and Bioinformatics Scientists • Partner with Production Engineering, Product, Bio Development, laboratory operations, and Data Science R&D • Establish standards for agent-assisted investigation and determine when conclusions require manual reproduction • Reduce recurring escalations and test turnaround time • Establish and maintain change validation and support processes

🎯 Requirements

• M.S. or Ph.D. in Bioinformatics, Computational Biology, Data Science, or a related technical discipline, or equivalent depth built through work • 5+ years working with genomic or sequencing data • 2+ years leading people • Demonstrated ownership of a support, escalation, or on-call function with commitments attached • Experience leading investigations across more than one system boundary through resolution • Ability to reach agreement across organizational lines without authority • Sequencing and bioinformatics fluency sufficient to distinguish pipeline failures from expected behavior • Ability to reconstruct events from logs, intermediate files, and pipeline outputs • Python and SQL for investigation, record retrieval, run comparison, and tool building • Experience with change control, validation, and documentation practices • Experience defining support processes, setting commitments, securing agreement, and staffing appropriately • Demonstrated people leadership, including developing, hiring, or repositioning team members • Understanding of laboratory operations and upstream data issues • Senior-level communication, negotiation, and persuasion skills • Machine learning or statistical analysis applied to genomic data is useful but not a gate • Experience with cell-free DNA, prenatal, or carrier screening applications is advantageous • Experience in an accredited or high-complexity laboratory or regulated diagnostic setting is advantageous • Familiarity with WDL, Nextflow, Snakemake, or Cromwell is advantageous • Experience building observability or alerting is advantageous

🏖️ Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents • Free testing for Natera employees and their immediate families • Fertility care benefits • Pregnancy and baby bonding leave • 401k benefits • Commuter benefits • Generous employee referral program