Associate Director, Pharmacokinetics – Pharmacodynamics

🔥 13 hours ago

🏄 California – Remote

🏄 California – Remote

💵 $185k - $205k / year

⏰ Full Time

🟠 Senior

👔 Director

👻 Ghost score 1%

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Atrium Therapeutics

WebsiteLinkedInAll Job Openings

11 - 50 employees

Founded 2026

🧬 Biotechnology

💊 Pharmaceuticals

Biotechnology • Pharmaceuticals

Atrium Therapeutics is a clinical-stage biotechnology company developing precision RNA medicines targeted to the heart. The company has a proprietary RNA delivery platform built on clinically validated AOC (antibody-oligonucleotide conjugate) technology originally designed at Avidity Biosciences, enabling delivery of oligonucleotide therapies directly into cardiac muscle while addressing cytotoxicity, immunogenicity, and redosing limitations. Atrium's pipeline includes lead candidates ATR-1072 for PRKAG2 syndrome and ATR-1086 for PLN cardiomyopathy, plus additional research-stage targets in rare cardiomyopathies; the company plans to file an IND for ATR-1072 in the second half of 2026. Atrium positions itself to pioneer precision cardiology by bringing RNA therapeutics to patients with genetic and rare forms of heart disease.

📋 Description

• Lead the pharmacokinetics and pharmacodynamics function at Atrium Therapeutics • Support all aspects of PKPD across programs from research into late-phase clinical development • Design, oversee, and interpret nonclinical and clinical PK, TK, and tissue distribution studies • Apply PKPD principles to relate exposure to target engagement and PD biomarkers • Inform dose selection and support first-in-human dose rationale • Assess immunogenicity impact on PK where relevant • Set phase-appropriate bioanalytical strategy • Oversee development of GLP-compliant PK and ADA assays in plasma and tissue matrices • Oversee CRO management, including RFP, SOWs, budget, timeline, and sample logistics • Represent PKPD on project and study teams • Communicate PKPD strategy and data interpretation • Support regulatory documents, including IND/CTA, briefing book, protocol, and CSR • Manage, mentor, and develop a team of PhD and non-PhD scientists • Set priorities, support career development, and build a collaborative, high-performing culture

🎯 Requirements

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, Biochemistry, or a related field • 8+ years of biopharma/biotech experience in nonclinical and clinical PKPD and regulated bioanalysis • Proven record of advancing programs from research into development • Experience authoring/supporting IND submissions and participating in regulatory interactions • Hands-on design and interpretation of nonclinical and clinical PK studies, including NCA • Strong understanding of PKPD principles • Working knowledge of regulated bioanalysis (ICH M10, GLP/GCP) • Experience overseeing PK and ADA assay development and sample analysis at CROs • Prior experience managing and developing scientific staff at multiple levels, including PhD and non-PhD scientists • Demonstrated ability to lead cross-functional initiatives and communicate complex data clearly to project teams and leadership • Comfortable with ambiguity, takes initiative, and is a hands-on problem-solver • Oligonucleotide (siRNA, ASO) and/or large-molecule experience preferred

🏖️ Benefits

• Stock options & RSUs • 401(k) with an employer match • Wellness program • Medical coverage • Dental coverage • Vision coverage • LTD coverage • Unlimited time off, including summer & winter breaks • Learning and development programming internally developed by and for Atrium employees • Job-specific training offered by industry • Education reimbursement program

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