Staff Scientist, Machine Learning – Genomics

🔥 2 minutes ago

🇺🇸 United States – Remote

💵 $167.4k - $209.2k / year

⏰ Full Time

🔴 Lead

🤖 Machine Learning Engineer

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Natera

WebsiteLinkedInAll Job Openings

1001 - 5000 employees

Founded 2004

🏥 Healthcare

🧬 Biotechnology

⚕️ Healthcare Insurance

Healthcare • Biotechnology • Healthcare Insurance

Natera is a global leader in cell-free DNA testing technology, specializing in non-invasive genetic testing and diagnostics. The company's innovative solutions focus on areas such as prenatal screening, cancer detection, and organ transplant monitoring. By using advanced bioinformatics and DNA analysis, Natera provides healthcare professionals and patients with critical information to make more informed medical decisions.

📋 Description

• Lead research on machine learning and deep learning models using NGS data • Frame problems, choose approaches, and determine when models merit further investment • Design, build, and benchmark models and features for Women Health and Organ Health products • Apply statistical learning and deep learning to high-dimensional, noisy, often small-sample sequencing data • Work directly with sequencing pipelines and outputs; trace issues through processing steps and distinguish pipeline, data, and biology problems • Build or extend pipeline components when needed • Partner with molecular biology and assay development scientists to design experiments, determine data and controls, and troubleshoot experiments • Establish rigorous validation, performance estimation, leakage prevention, and documentation practices • Contribute to Natera's intellectual property portfolio through invention disclosures and patent work • Contribute to scientific publications and presentations where appropriate • Mentor data scientists and bioinformaticians, review their work, and provide technical leadership • Use AI tools and coding agents for implementation, analysis, and review while owning delivered work • Collaborate with R&D and product teams to define requirements and improve products and processes

🎯 Requirements

• M.S. or Ph.D. in a quantitative field such as Computer Science, Applied Mathematics, Statistics, Bioinformatics, Computational Biology, Engineering, or similar; equivalent depth built through work counts fully • 6+ years of hands-on experience in machine learning and data analysis on biological or genomic data after your degree • Demonstrated track record of models or algorithms led that reached real use • Depth in next-generation sequencing data analysis, including sequencing QC, alignment and quantification, normalization, and sequencing artifacts • Working fluency with NGS bioinformatics pipelines, including running, reading code and logs, tracing processing steps, diagnosing failures, and modifying pipeline components • Extensive practical experience with machine learning, deep learning, and statistics, including model validation and performance estimation on limited or imbalanced data • Advanced Python, including open-source ML libraries such as scikit-learn, PyTorch, TensorFlow, and XGBoost, in a cloud environment • Experience processing large datasets and working with a query language such as SQL • Ability to apply mathematical and statistical principles to real estimation problems and develop practical solutions • Familiarity with assay development and analysis pipelines for molecular or clinical biomarkers • Clear communication of technical results to non-specialists and experience delivering complex projects with cross-functional teams • Preferred: experience with RNA-seq and small RNA/miRNA • Preferred: experience building probabilistic models for NGS and omics data • Preferred: experience with diagnostic product development in a regulated or CLIA/CAP setting • Preferred: experience with Nextflow, WDL, Snakemake, Docker, AWS, or GCP • Preferred: patents, peer-reviewed publications, or conference presentations

🏖️ Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents • Free testing for Natera employees and their immediate families • Fertility care benefits • Pregnancy and baby bonding leave • 401k benefits • Commuter benefits • Employee referral program

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