
51 - 200 employees
Founded 2017
🧬 Biotechnology
🏥 Healthcare
💊 Pharmaceuticals
Biotechnology • Healthcare • Pharmaceuticals
Cabaletta Bio is a clinical-stage biotechnology company developing engineered T cell therapies to treat autoimmune diseases. Using its CABA® (Cabaletta Approach to B cell Ablation) platform, the company is advancing rese-cel, a fully human CD19 CAR T cell candidate with a 4-1BB co-stimulatory domain, in multiple RESET™ Phase 1/2 trials for systemic lupus erythematosus, myositis, systemic sclerosis, generalized myasthenia gravis, and pemphigus vulgaris. Cabaletta aims to deliver deep, durable, potentially curative responses by transiently eliminating B cells to reset immune tolerance, and emphasizes patient-centered development and broad indication expansion across rheumatology, dermatology, and neurology.
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51 - 200 employees
Founded 2017
🧬 Biotechnology
🏥 Healthcare
💊 Pharmaceuticals
Biotechnology • Healthcare • Pharmaceuticals
Cabaletta Bio is a clinical-stage biotechnology company developing engineered T cell therapies to treat autoimmune diseases. Using its CABA® (Cabaletta Approach to B cell Ablation) platform, the company is advancing rese-cel, a fully human CD19 CAR T cell candidate with a 4-1BB co-stimulatory domain, in multiple RESET™ Phase 1/2 trials for systemic lupus erythematosus, myositis, systemic sclerosis, generalized myasthenia gravis, and pemphigus vulgaris. Cabaletta aims to deliver deep, durable, potentially curative responses by transiently eliminating B cells to reset immune tolerance, and emphasizes patient-centered development and broad indication expansion across rheumatology, dermatology, and neurology.
• Lead the global monthly S&OP cycle, including Demand Review, Supply Review, and support for Executive S&OP. • Partner with Clinical, Commercial, Finance, Quality, Regulatory, and Manufacturing to produce an aligned operating plan. • Build and maintain consensus demand plans for clinical and commercial products. • Prepare executive S&OP materials, frame decisions and recommendations, and track action items to closure. • Oversee end-to-end supply models across the cell therapy value chain, including MCB, plasmids, LVV, apheresis, DP, product control, and reference standards. • Guide long-range requirements modeling for critical starting materials. • Translate patient demand into apheresis collection and drug product manufacturing slot requirements. • Ensure supply plans support release testing, stability programs, and comparability studies. • Identify, quantify, and escalate supply constraints and regulatory dependencies. • Partner with Supplier Management and CDMOs on forecasts, slot offers, and capacity planning. • Lead scenario planning for supply, inventory, and capacity risks and recommend network design changes. • Oversee inventory strategy execution, including reconciliation, shelf-life and expiry management, and minimizing excess and obsolete write-offs. • Lead, coach, and develop a team of supply planning and inventory professionals. • Perform other duties as assigned.
• Bachelor’s degree or equivalent (preferred concentration in Engineering, Supply Chain, or Business Management/Sciences); advanced degree (MBA or MS) a plus. • 7-10 years of progressive supply chain experience spanning demand planning, supply planning, and/or S&OP. • Relevant experience in autologous cell & gene therapy is ideal. • People leadership experience. • Ability to facilitate executive-level discussions, synthesize complex data into clear recommendations, and influence cross-functional stakeholders. • Experience with ERP (NetSuite preferred) and planning systems and advanced Excel skills. • Experience with BI/visualization tools such as Power BI or Tableau a plus. • APICS (CPIM/CSCP) or similar certification preferred. • Working knowledge of regulatory frameworks such as FDA and EMA, GMP manufacturing, and GMP storage requirements.
• Competitive benefits • PTO • Stock option plans • Commitment to employee well-being and continuous growth
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